Revolution for Dogs (Selamectin)
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PetMD’s medications content is written and reviewed by veterinary professionals to answer common questions about how medications work, their side effects, and what species they are prescribed for. This content should not replace advice from your veterinarian.
Key Takeaways
- Revolution is an FDA-approved topical medication that protects dogs against fleas, heartworms, ear mites, sarcoptic mange, and American dog ticks.
- Apply Revolution once a month year-round exactly as directed by your veterinarian.
- Side effects are uncommon but may include mild skin irritation, vomiting, diarrhea, or decreased appetite.
- Use only the product labeled for your dog's species and weight.
What Is Revolution Used for in Dogs?
With its active ingredient, selamectin, Revolution for dogs is an FDA-approved topical medication that protects against flea infestations and heartworm disease.
It also treats and controls:
- Ear mites
- Sarcoptic mange
- American dog tick infestations
Revolution is approved for dogs and puppies 6 weeks of age and older.
Revolution Considerations for Dogs
Before using Revolution:
- Do not use it in sick, debilitated, or underweight dogs.
- Revolution has been shown to be safe for pregnant, breeding, and nursing dogs.
How Does Revolution Work in Dogs?
The active ingredient in Revolution, selamectin, kills certain parasites by disrupting their nerve and muscle function, causing paralysis and death.
How Do You Give Revolution to Dogs?
Follow the directions on the drug label or your veterinarian’s instructions.
To apply Revolution:
- Make sure your dog's skin and coat are dry.
- Part the fur between the shoulder blades and apply the entire contents of the tube directly to the skin.
- Prevent your dog from licking the medication until it has dried.
Apply Revolution once every 30 days.
Temporary hair clumping, discoloration, or a powdery residue at the application site is normal. These effects are temporary and do not affect the safety or effectiveness of the medication.
Wait at least two hours before bathing your dog.
Always use the product labeled for your dog's species and weight. Using cat flea and tick medication on dogs—or dog products on cats—can be dangerous.
What Happens If You Miss a Dose of Revolution?
Give the missed dose as soon as you remember and resume monthly applications. Let your veterinarian know about the missed dose.
If your veterinarian has prescribed a different dosing schedule, contact them for instructions. Never apply a double dose to make up for a missed one.
What Are the Side Effects of Revolution in Dogs?
Most dogs tolerate Revolution well. When side effects occur, they may include:
- Irritation or hair loss at the application site
- Vomiting
- Diarrhea
- Loss of appetite
- Lethargy
- Drooling
- Increased breathing rate
- Tremors
- Fever
- Generalized itching
- Hives
- Lack of coordination
- Seizures
Contact your veterinarian if your dog develops severe side effects or appears ill after treatment.
Human Side Effects
Humans should never use medication prescribed for pets, and pets should never be given medication prescribed for humans.
Avoid touching the application site until it's completely dry. Wash your hands after applying Revolution and wash off any product in contact with the skin immediately with soap and water.
Revolution may irritate the skin or eyes. If any contact with eyes occurs, flush eyes copiously with water.
Rarely, people may experience skin irritation, itching, hives, or redness after contact with the medication.
If you accidentally ingest a pet medication, seek medical attention or call Poison Control at 800-222-1222.
Monitoring Your Dog
Dogs should be tested for heartworm infection before starting Revolution. If your dog tests positive, your veterinarian can recommend a treatment plan specifically targeted to eliminate adult heartworms. Revolution can only eliminate heartworm larvae and prevent future heartworm infections. Your veterinarian may recommend additional monitoring based on your dog's health and medical history.
When Should You Call Your Veterinarian?
Contact your veterinarian if:
- Your dog develops severe side effects
- Your dog's condition worsens or doesn't improve
- You suspect an overdose
- You have questions about using Revolution
What Happens If a Dog Overdoses on Revolution?
Topical overdoses usually don't cause symptoms beyond the side effects listed above, but if you suspect your dog received too much medication, seek emergency veterinary care or contact an animal poison control center immediately. Consultation fees may apply.
- Pet Poison Helpline: 855-764-7661
- ASPCA Animal Poison Control: 888-426-4435
How To Store Revolution for Dogs
Store Revolution according to these guidelines:
- Keep the medication in its original packaging until you're ready to apply it.
- Store at temperatures below 86 F (30 C).
- Protect the medication from heat, open flames, moisture, and light.
- Keep out of reach of children and pets.
Revolution for Dogs FAQs
Can I use Revolution for cats on my dog?
No, Revolution for cats cannot be used on dogs. Always use the Revolution product labeled for your pet's species and weight, as the doses for dogs and cats are different.
Do I need a prescription for Revolution?
Yes. Revolution is available only by prescription from your veterinarian. It’s important to work with your vet to ensure the best broad-spectrum parasite prevention plan for your dog.
How often should I apply Revolution?
Apply Revolution once every 30 days to provide continuous protection against fleas, heartworms, ear mites, scabies mites, and American dog ticks.
No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. All content is sourced from public references or the manufacturer.
