Ketoconazole

PetMD Editorial
Written by:
PetMD Editorial
Published: November 7, 2012

Drug Info

  • Common Name: Nizoral®, Ketochlor®
  • Drug Type: Antifungal
  • Species: Dogs, Cats
  • Available Forms: 200 mg tablets, shampoo
  • FDA Approved: No

General Description

Ketoconazole is an antifungal drug effective against fungus of the lymph nodes, skin, nails, respiratory system, bone, and other parts of your pet’s body. A shampoo that mixes Ketoconazole with Chlorhexidine is used to treat fungal and bacterial skin infections.

Other forms of this drug- Itraconazole and Fluconazole- have been produced to improve upon the number of side effects and effectiveness for certain types of infections. Some fungi have shown resistance to Ketoconazole, such as Candida albicans.

Giving Ketoconazole with food may assist with absorption and reduce stomach upset.

How It Works

Ketoconazole works by inhibiting production of the fungal cell wall. This causes the fungus to be structurally inadequate so that it leaks and dies. In smaller doses, in can be used to inhibit the reproduction of the fungus.

Storage Information

Store in a tightly sealed container at room temperature and protected from heat or light.

Missed Dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Ketoconazole may result in these side effects:

  • Inhibited synthesis of cortisone
  • Dizziness
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Bleeding of the mouth
  • Sensitivity to light

Ketoconazole also blocks the systhesis of cortisone in the adrenal gland, which in some cases may be a harmful side effect, but when used correctly, it’s an effective treatment against Cushing’s syndrome.

Ketoconazole may react with these drugs:

  • Aminophylline
  • Cisapride
  • Astemizole
  • Triazolam
  • Cyclosporine
  • Methylprednisolone
  • Mitotane
  • Phenytoin sodium
  • Rifampin
  • Theophylline
  • Warfarin sodium
  • H2 Blockers
  • Antacids

DO NOT GIVE KETOCONAZOLE TO PREGNANT PETS

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH LIVER DISEASE


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