Sileo for Dogs

Sileo, also known as dexmedetomidine oromucosal gel, helps treat fear and anxiety triggered by loud noises in dogs.  

Here’s how it works, when to give it to your dog, and possible side effects.  

What Is Sileo Used for in Dogs?

Sileo, also known as dexmedetomidine oromucosal gel, helps treat fear and anxiety triggered by loud noises in dogs. 

Your veterinarian may prescribe Sileo to help your dog feel calm when exposed to fireworks, construction work, vacuum cleaners, thunderstorms, and any other loud environment that may trigger anxiety. 

Is Sileo FDA-Approved for Dogs? 

Yes, Sileo is the first FDA-approved medication for the treatment of fear and anxiety triggered by loud noises in dogs. 

Sileo Considerations for Dogs

Dogs should have a clean bill of health and clearance from their vet to take Sileo.  

Sileo should not be used in dogs with certain medical conditions, such as:   

• Heart disease 
• Respiratory disorders  
• Shock 
• Liver disease  
• Kidney disease 
• Dental or gum disease 
• Severe debilitation—in other words, a medical or behavioral condition that is so serious that it limits a dog's quality of life 

This medication also shouldn’t be prescribed to dogs who are:  

• Stressed due to fatigue 
• Exposed to extreme weather (hot or cold)  
• Hypersensitive to Sileo (while rare, an allergic reaction to Sileo or one of its inactive ingredients could cause facial swelling, hives, intense itch, vomiting, diarrhea, restlessness, difficulty breathing, pale gums, and loss of consciousness)  

Because more safety studies are needed, do not give Sileo to dogs who are:  

• Pregnant 
• Breeding 
• Lactating dogs  
• Puppies (younger than 16 weeks old) 
• Seniors (7+ years for many breeds)  

Giving Sileo with certain medications can result in health risks to your pet, so it’s important to discuss your pet’s medications and medical conditions with your veterinarian first. 

How Does Sileo Work in Dogs?

The active ingredient in Sileo is dexmedetomidine, which is classified as an alpha-2-adrenergic agonist. 

Sileo decreases fear and anxiety in pets by binding to alpha-2-adrenergic receptors in the brain. This prevents norepinephrine, a specific “fight-or-flight” chemical involved in the body’s response to stress, from being released.  

When norepinephrine levels are lowered in the brain, your pet will exhibit fewer of the physical and behavioral signs associated with anxiety and fear, such as trembling, excessive barking, and restlessness. 

How Do You Give Sileo to Dogs?

Follow the directions on the client information sheet and drug label or as provided by your veterinarian. 

• Sileo is an oromucosal gel, meaning it’s placed inside the mouth between your dog’s cheek and gums, where it’s absorbed. It may not be effective if swallowed. 
• Wear gloves when administering this gel to your dog. It must be given by an adult.  
• Give Sileo 30–60 minutes before the anxiety-triggering noise event or immediately after your dog starts to show signs of fear and anxiety.  
• When dialing the appropriate dose on the syringe, the ring-stop must be locked in place prior to administration. If the ring-stop is not fully locked before dosing, an accidental overdose may occur. 
• Do not give your dog food, treats, or water after administration, as this may water down the gel and reduce how much medication is absorbed. Wait a few hours until the effects have worn off. 
• If Sileo is swallowed, do not repeat the dose for at least two hours to avoid overdose in case some of the medication was already absorbed through the gums and cheek. 
• Keep your dog warm and comfortable while Sileo is taking effect. The medication reduces body temperature as the level of sedation decreases. This also helps with a calm and safe recovery when the medication wears off. Make sure they have a soft blanket and cozy bed available at all times. Some dogs will appreciate a heating pad too.  

• If your dog is still showing signs of fear or anxiety after taking Sileo, contact your veterinarian before giving another dose. 
• Do not give Sileo to a dog who is still sleepy or sedated from a previous dose. 

What Happens If You Miss a Dose of Sileo? 

Speak with your veterinarian about what to do if a dose is missed.  

Generally, your vet may instruct you to give it when you remember, or if it’s almost time for your dog’s next dose, to skip the missed dose and resume your normal dosing schedule. 

Do not give extra or double doses. 

What Are the Side Effects of Sileo in Dogs?

Sileo is typically well-tolerated in most dogs. 

Possible side effects include: 

• Pale gums where Sileo was applied  
• Drowsiness 
• Weakness 
• Vomiting 
• Loss of balance 
• Muscle tremors 
• Inappropriate urination 

Human Side Effects 

Humans should never take medication prescribed for pets, and pets should not be given medication prescribed for humans. Dosages often differ significantly. 

Here are some things to keep in mind when handling Sileo:  

• Wear impermeable disposable gloves when handling and using filled syringes, administering Sileo, and during any contact with your dog's mouth after application. Sileo can be absorbed through your skin, mucous membranes (mouth and gums), and eyes.  
• Avoid handling and administering Sileo if you’re pregnant, because it can be absorbed through the skin and may induce uterine contractions and/or decrease your baby’s blood pressure.  

If you accidentally ingest a pet medication, seek medical attention or call Poison Control at 800-222-1222. 

Monitoring Your Pet 

No specific monitoring is required for this medication, but your veterinarian may recommend routine testing depending on your dog’s individual needs, other medications that may be prescribed, and/or the issue that initially caused your dog to be placed on this medication. 

When Should You Call Your Veterinarian? 

Call your veterinarian if you see any of the following, or if you have additional questions or concerns about the use of Sileo: 

• Severe side effects occur  
• Your pet’s condition worsens or does not improve  
• You suspect an overdose 

What Happens If a Pet Overdoses on Sileo?

Signs of an overdose of Sileo may include:  

• Sedation  
• Inappropriate urination 
• Vomiting 
• Loss of balance 
• Weakness 
• Fainting due to abnormally slow heart rate (bradycardia) 

If you suspect an overdose, seek emergency veterinary care or contact an animal poison control center. Consultation fees may apply. 

• Pet Poison Helpline: 855-764-7661
• ASPCA Animal Poison Control: 888-426-4435 

How Should Sileo Be Stored for Dogs?

Keep the following storage tips in mind for this medication: 

• Store Sileo oromucosal gel syringes (unopened or opened) in the original package at controlled room temperature, 68–77 F (20–25 C). Brief exposure to 59–86 F (15–30 C) are permitted. 
• After use, recap the syringe and return it to the original package to protect it from light and moisture. Make sure the package is closed properly.  
• Use or discard syringe contents within four weeks of opening. 
• Keep out of reach of children and pets.