PetMD Editorial
Written by:
PetMD Editorial
Published: November 7, 2012

Drug Info

  • Common Name: Revolution®
  • Drug Type: Parasiticide
  • Used For: Treatment of fleas, ticks, heartworms, mites
  • Species: Dogs, Cats
  • Administered: Topical medication
  • How Dispensed: Prescription only
  • FDA Approved: Yes

General Description

Selamectin is used to prevent flea infestations on your pet. In dogs, it is also effective against ticks, sarcoptes mites, ear mites, and heartworms. In cats, it is also effective against roundworms, hookworms, ear mites, and heartworms.

How It Works

Selamectin works by entering your pets bloodstream through the skin. There, it can kill internal parasites such as the heartworm by paralyzing their central nervous system. Selamectin also redistributes itself back to the skin from the bloodstream to treat external parasites such as ticks, fleas, and mites. Fleas are typically dead within 36 hours of administration.

Selamectin is not effective against the adult form of the heartworm, so it important to test your pet for heartworms before administering Revolution®. Selamectin is to be given every 30 days, preferably on the same day every month.

Do not give your pet Selamectin by mouth! To administer Selamectin topical solution, you want to puncture the seal on the tube using the cap. Then, spread the hair on the back of your pet’s neck above the shoulder blades to expose the skin. Squeeze and drag the entire contents of the tube onto the skin. Do not massage into skin, and do not apply to wet or broken skin.

Do not bathe your pet within two hours of giving Selamectin.

Storage Information

Store at room temperature.

Missed Dose?

Give the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Selamectin may result in these side effects:

  • Allergic reaction (labored breathing, hives, etc)
  • Loss of appetite
  • Drooling
  • Vomiting
  • Diarrhea
  • Muscle tremors
  • Fever
  • Rapid breathing

Do not use Selamectin concurrently with any other topical flea preventative. Selamectin is, however, safe to use in pregnant or lactating pets. Revolution® is also safe for use in dogs over 6 weeks of age and cats over 8 weeks.

The administration of Selamectin may result in oily, stiff, discolored, or powdery hair or skin at the administration site. Irritation and hair loss at the site may also occur, but should be temporary.

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