- Drug Name: Metoclopramide
- Common Name: Reglan®, Clopra®, Maxalon®, Octamide®, Reclomide®
- Drug Type: Gastrointestinal prokinetic
- Used For: Megaesophagus, Acid reflux, Megacolon
- Species: Dogs, Cats
- Administered: 5mg, 10mg tablets, Oral liquid, Injectable
- How Dispensed: Prescription only
- FDA Approved: No
Metoclopramide is given to help with the quick passage of food through the upper digestive tract. It may be used to treat disorders of the upper gasto-intestinal tract such as acid reflux disease.
Metoclopramide is often used as an anti-vomiting drug. In otherwise healthy pets that have a chronic vomiting problem due to delayed gastric emptying, Metoclopramide helps reduce the delay by speeding up the passage of food. Chronic vomiting of this type is typically characterized by a small amount yellowish bile vomit, usually in the mornings.
How It Works
The muscles in the stomach contract to pass food at a certain pace known as it’s motility. Motility can be inconsistent or abnormal due to a number of disorders. Reduced motility leads to a build-up of food in the stomach which causes bloating and nausea. Metoclopramide increases the release of acetylcholine, which in turn stimulates the smooth muscle in the digestive tract to contract more frequently.
Metoclopramide also increases the muscle tone of the upper GI tract and esophagus.
It is also able to cross the blood-brain barrier and act on the mental signal for nausea. This is particularly useful in the treatment and prevention of nausea and vomiting in pets undergoing chemotherapy treatment.
Store in a tightly sealed container at room temperature.
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.
Side Effects and Drug Reactions
Metoclopramide may result in these side effects:
- Increases seizure activity in epileptics
- Changes in behavior
- Abdominal pain
Metoclopramide may react with these drugs:
- Central nervous system depressant or sedative
- Derivatives of Tetracycline
USE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH AN OBSTRUCTION OR PERFORATION IN THEIR DIGESTIVE TRACT
USE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH EPILEPSY OR SEIZURE DISORDERS