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Drug Info

  • Drug Name: Cyclosporine Ophthalmic Ointment
  • Common Name: Optimmune
  • Generics: No
  • Drug Type: Immunosuppressant
  • Used For: Keratoconjunctivitis (KCS, ‘dry eye’)
  • Species: Dogs
  • Administered: Ophthalmic
  • How Dispensed: Prescription Only
  • Available Forms: 0.2% 3.5gm
  • FDA Approved: Yes, for dogs


Cyclosporine ophthalmic (Optimmune) is indicated for the treatment of keratonconjnctivitis sicca (KCS) and chronic superficial keratitis in dogs. KCS (aka dry eye syndrome) is usually a lifetime required treatment.

Dosage and Administration

Cyclosporine Ophthalmic should be used according to your veterinarian’s instructions. Prior to applying the ointment, if discharge is present, clean with a sterile eyewash solution recommended by your veterinarian.

Please note that the ointment may temporarily blur your dog’s vision; please watch your pet to avoid any injury from bumping into objects.

Missed Dose?

If a dose of Cyclosporine Ophthalmic (Optimmune) is missed, apply the dose as soon as possible. If you remember when it is almost time for the next dose, skip the one you missed and get back on your regular schedule. Do NOT double the dosing.

Possible Side Effects

Side effects from Cyclosporine Ophthalmic are rare due to the low dose concentration of cyclosporine. Most common side effects of Cyclosporine Ophthalmic include:

  • Eye irritation (redness, rubbing at the eye, excessive blinking)

Please contact your veterinarian if the side effects persist or worsen within a week of treatment.


Do not use in dogs that are allergic to Cyclosporine. Do not use in dogs that have either a viral or fungal eye infection.

The safe use of cyclosporine ophthalmic (Optimmune) has not been determined in puppies, breeding, pregnant, or lactating dogs.


Cyclosporine Ophthalmic (Optimmune) should be stored between 36°-77°F (2°C - 25°C). Additionally, as with any medication, keep out of children’s reach.

Drug Interactions

When using Cyclosporine Ophthalmic, please inform your veterinarian of any other medications your pet is currently taking, including supplements, as interaction could occur.

If applying other eye medications please wait at least five minutes before applying cyclosporine ophthalmic (Optimmune).

Signs of Toxicity/Overdose

It is unlikely to overdose with eye medications but if ingested, it could cause liver and kidney damage. If you suspect or know you dog has ingested Cyclosporine Ophthalmic, please contact your veterinarian or emergency vet clinic immediately. 

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