DHPP Vaccination for Dogs (5-in-1 Vaccine): What To Know

Natalie Stilwell, DVM, MS, PhD
By Natalie Stilwell, DVM, MS, PhD. Reviewed by Veronica Higgs, DVM on Mar. 3, 2024
A dog gets a vaccine from their vet.

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What Is the DHPP Vaccine for Dogs?

Vaccinating your dog is an important part of being a pet parent. The most common vaccines are typically given together in a single shot that’s known as the DHPP vaccine, 5-in-1 vaccine for dogs, or 5-way puppy shot.

This combination vaccine is considered a core vaccine—meaning all dogs should get it. Core vaccines tend to protect against viruses that are highly contagious, cause serious disease, and have high fatality rates.

Let’s look at what pet parents should know about the DHPP vaccine for dogs, including the diseases it protects against and how often it’s administered.

What’s Included in the DHPP Vaccine for Dogs?

The 5-in-1 vaccine for dogs is typically referred to by its acronym (DHPP, DAPP, or DA2PP) to indicate the diseases it protects against. This vaccine includes protection against:

These diseases are all caused by viruses with no known cure, so vaccination is the primary way to keep dogs protected. They are also highly contagious, and dogs of all ages are at risk of becoming infected.

How Often Does My Dog Need the DHPP Vaccine?

Puppies will need a series of vaccines to be fully vaccinated. For DHPP that means getting one at 6 to 8 weeks of age and then every 2 to 4 weeks until the pup is 16 weeks old.

After the initial puppy series, dogs will get a booster every one to three years depending on the vaccine manufacturer’s label and your veterinarian’s recommendation.

Benefits of the DHPP Vaccine for Dogs

The 5-in-1 vaccine for dogs offers many advantages over single-pathogen vaccines. Your dog will only need to receive one shot during each visit rather than five, which saves time and money and minimizes your pet’s discomfort.

This combo vaccine can even include noncore vaccines, like leptospirosis, which means your pup can get maximum protection without having to get multiple shots.

Side Effects of the DHPP Vaccine for Dogs

Core vaccines such as DHPP are important for the health and wellbeing of your pup. While vaccine reactions are typically rare, it’s important to know what to watch for. Potential signs of a mild vaccine reaction include:

These signs should be mild and last less than 24 hours. It's important to have a nice place for your pup to lay down and rest after their vaccination appointment and get a few extra snuggles.

If your pet experiences symptoms more severe or lasting longer, contact your veterinarian. 

Additionally, while very rare and uncommon, occasionally vaccines such as DAPP can cause life-threatening anaphylactic reactions. If you notice any of the following signs, please see your vet or an emergency vet immediately:

What Does the DHPP Vaccine for Dogs Cost?

The cost of vaccines can vary significantly depending on the geographic area of the country as well as the type of clinic (general practice versus animal shelter), but the typical estimate of the DHPP vaccine for dogs costs $25-50 per dose. 

Many pet insurance companies offer wellness or preventative care plans which cover puppy and annual vaccinations.  This may be a good option to help offset vaccination costs.

Natalie Stilwell, DVM, MS, PhD


Natalie Stilwell, DVM, MS, PhD


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