Foot/Toe Cancer in Dogs

4 min read

Digital Squamous Cell Carcinoma in Dogs

Dogs can be afflicted with several types of skin tumors, even on their feet and toes. The most common type of type of tumor to affect the toes is a squamous cell carcinoma. A squamous cell carcinoma (SCC) can be described as a malignant and particularly invasive tumor that takes hold in the scale like cells of the epithelium – the tissue that covers the body or lines the cavities of the body. These scale like tissue cells are called the squamous.

Carcinoma is, by definition, an especially malignant and persistent form of cancer, often returning after is has been excised from the body and metastasizing to other organs and locations on the body.

A squamous cell carcinoma usually comes from the skin around the nail. It commonly affects the bone and tissue around it, spreading slowly enough that it can be caught before it is able to spread to other areas of the body. In dogs, squamous cell carcinomas usually affect only one toe. The tumor may appear as a small nodule, a reddish colored skin plaque, or as a papule – small and blister like in appearance, but differentiated by its lack of fluid. The SCC does not retain its appearance as a solid mass. Over time it will grow, the tissue within the mass will die (necrotize), and the tumor will ulcerate.

Large breed dogs and black colored dogs are more likely to be affected by these tumors. Labrador retrievers and standard poodles appear to be more vulnerable than other breeds. And, as with most types of carcinomas, squamous cell carcinoma is most likely to be seen in older dogs, around ten years old, though it has been also been diagnosed in younger dogs.

Symptoms and Types

  • Swollen toe or foot
  • Limping, reluctance to walk
  • Ulcer (sore) on toe
  • Bleeding ulcer on a toe
  • Broken nail on a toe with a sore
  • Solid, raised mass of skin on the toe (i.e., nodule, papule)
  • Usually only one toe is affected
  • May be without other symptoms


There is no known cause of squamous cell carcinomas of the toe in dogs.


You will need to provide a thorough history of your dog's health leading up to the onset of symptoms. Be sure to describe any sores that have been apparent on other parts of the body, even if you suspect they were caused by injuries resulting from outdoor activity, or from scratching at the skin. During the examination, your veterinarian will look carefully for other sores or tumors on your dog's body. The lymph nodes will be carefully felt to determine if they are enlarged, an indication that the body is reacting to an infection or invasion. A sample of lymph fluid may be taken to test for cancerous cells. Your veterinarian will order complete blood count and biochemistry profile to make sure your dog's other organs are working normally and to determine whether the white blood cell count is higher than normal; again, an indication that the body is fighting an invasive disease or infection.

X-rays images of your dog's chest will allow your veterinarian to visually inspect the lungs for signs of any abnormalities, especially tumors. X-rays of your dog's foot will also be ordered to determine how deep the tumor is in the tissue and whether the tumor on the toe has spread to the bones in the foot. A biopsy will be taken of the tumors so that your doctor can diagnose the specific type of growth it is, whether carcinoma or a benign mass of tissue. If your dog has sores or tumors in other areas, your veterinarian will also order biopsies of these for analysis.

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