Liver Fluke Infestation in Cats

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Opisthorchis Felineus Infection in Cats

The cat liver fluke, also known as Opisthorchis felineus, is a trematode parasite that lives in water. It hitches a ride with an intermediate host, typically the land snail, which is then ingested by another intermediate host, such as the lizard and frog. It is at this point that a cat will eat the host (i.e., the lizard), becoming infected with the organism. The fluke makes its way into the biliary tract and liver, leading to a diseased state.

Liver fluke infection occurs most in cats in Florida, Hawaii, and other tropical and subtropical areas. Approximately 15 to 85 percent of cats with access to intermediate hosts are infected in endemic areas (areas in which this trematode parasite occurs naturally). The typical patient is a young feral cat between the ages of 6 to 24 months with access to local wild life.

Symptoms and Types

The severity of symptoms depend on the severity of infection. However, most infested cats remain asymptomatic. Otherwise, your cat may display one or more of the following symptoms:

  • Vomiting
  • Loss of appetite (anorexia)
  • Emaciation/ severe weight loss
  • Mucoid diarrhea
  • Jaundice
  • Enlarged liver
  • Abdominal distention
  • Generalized disability
  • Fever


The life cycle of O. felineus requires two intermediate hosts living in a tropical or subtropical climate. The life cycle is cyclical, with the embryonated eggs passing from an infected cat through its feces. The infected feces is then ingested by the first intermediate host, a land snail. The larvae hatch in the snail, penetrating the host's tissue and developing sporocysts, a sac like larval stage. The mature daughter sporocysts emerge from the snail and are thereafter ingested by a second intermediate host, usually an anole lizard (but also skinks, geckos, frogs, and toads). They then enter the second host's bile ducts, where they reside until the host is ingested by a cat.

Infection takes place when the Cercariae are released in the upper digestive tract of the cat and they migrate to the bile ducts (ducts of the liver) and gallbladder, where they mature and shed eggs within eight weeks.

Risk factors for infection are living in a tropical or subtropical climate in which the appropriate intermediate hosts reside, access to an outdoor or indoor/outdoor environment, successful hunting skills, and consumption of an infected intermediate host.


You will need to give a thorough history of your cat's health, onset of symptoms, and lifestyle behaviors, such as whether your cat is allowed outdoor access. This disease is differentiated from others that might have similar symptoms by taking fluid and tissue samples from the liver or bile for laboratory analysis. It can also be definitively diagnosed from a microscopic examination of biopsied liver tissue, as well as by discovery of eggs in the feces.

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