Solensia for Cats: Uses, Cost, and Side Effects

PetMD’s medications content is written and reviewed by veterinary professionals to answer common questions about how medications work, their side effects, and what species they are prescribed for. This content should not replace advice from your veterinarian. 

What Is Solensia Used for in Cats?

Solensia (frunevetmab) is an FDA-approved monthly injection used to control pain associated with osteoarthritis in cats. 

It’s administered once every four weeks by a veterinarian and is currently the only FDA-approved treatment for this indication in cats. 

Solensia Considerations for Cats

Solensia may not be appropriate for all cats. Talk with your veterinarian before starting Solensia if your cat: 

• Has a known hypersensitivity (allergy) to frunevetmab 

• Is breeding, pregnant, or lactating 

• Is a kitten 

• Has other chronic health conditions​, ​such as kidney disease​​​​ 

Always share your cat’s full medical history and current medications or supplements with your veterinarian before starting Solensia. 

How Does Solensia Work in Cats?

Solensia works by targeting and blocking nerve growth factor (NGF), a protein that plays a major role in osteoarthritis pain. When NGF is blocked, fewer pain signals are sent to your cat’s brain. 

Frunevetmab, the active ingredient in Solensia, is a monoclonal antibody—a type of protein made to attach to one specific target in the body. In cats with osteoarthritis, NGF contributes to joint pain and inflammation. By attaching to NGF, Solensiahelps reduce discomfort and improve mobility. 

How Do You Give Solensia to Cats?

Solensia is given by your veterinarian and is not available for at-home use. Your veterinarian will: 

• Determine the dose based on your cat’s weight  

• Administer it as an under-the-skin (subcutaneous) injection once every four weeks 

• Give it in the clinic so they can assess your cat’s pain and monitor their response to treatment 

What Happens If You Miss a Dose of Solensia? 

If you forget to bring your cat in for their monthly injection, please contact your veterinarian.  

In general, your vet will schedule an appointment for your cat every four weeks to administer the injection and observe your cat’s response to Solensia.  

What Are the Side Effects of Solensia in Cats?

Solensia is generally well tolerated, but side effects can occur. 

Common side effects include: 

• ​​Vomiting​ 

• ​​Diarrhea​ 

• Pain at the injection site 

• Scabs on the head and neck 

• ​​Itchy skin​ 

Do not use Solensia in cats with a known hypersensitivity to frunevetmab. The safe use of Solensia has not been established in breeding, pregnant, or lactating cats. 

Human Side Effects 

Solensia is not approved for use in humans. Because it’s given in a veterinary clinic, the risk of accidental exposure is low, but reactions are possible. 

• Pregnant or breastfeeding individuals, or those trying to conceive, should avoid handling the syringe. 

• Hypersensitivity (allergic) reactions may occur with accidental self-injection. 

If accidental self-injection occurs, seek medical attention right away and bring the product label or package information with you. 

If you accidentally ingest a pet medication, seek medical attention or call Poison Control at 800-222-1222. 

Monitoring Your Pet 

No specific monitoring is required for this medication, but your veterinarian may recommend routine testing depending on your cat’s individual needs, other medications that may be prescribed, and/or the issue that initially caused your cat to be placed on this medication. 

When Should You Call Your Veterinarian? 

Call your veterinarian if you see any of the following, or if you have additional questions or concerns about the use of Solensia: 

• Severe side effects occur  

• Your pet’s condition worsens or does not improve  

• You suspect an overdose 

What Happens If a Pet Overdoses on Solensia?

Solensia is generally well tolerated, but an overdose may increase the risk of side effects. 

Signs of an overdose may include: 

• Vomiting 

• Diarrhea 

• Scabs or skin sores 

• Itching 

• ​​Hair loss​ 

• ​​Lethargy​ 

If you suspect an overdose, seek emergency veterinary care or contact an animal poison control center. Consultation fees may apply. 

• Pet Poison Helpline: 855-764-7661 

• ASPCA Animal Poison Control: 888-426-4435 

How Should Solensia Be Stored?

Solensia is stored and handled by your veterinary clinic. The medication is: 

• Kept refrigerated between 35–46 F (2–8 C). 

• Stored in the original carton to protect from light.