Piroxicam

PetMD Editorial
November 07, 2012
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General Description

Piroxicam is a Non-Steroidal Anti-Inflammatory drug (NSAID) used for the treatment of inflammation. It is typically prescribed to pets with joint disease, fevers, and minor aches. It is also effective in the treatment of cancer, especially bladder cancers.

How It Works

NSAIDs work by reducing the enzyme COX-2. COX-2 is involved in the formation of prostaglandins which cause swelling and inflammation. Reduction of these factors reduce the pain and inflammation your pet experiences.

It is difficult to inhibit COX-2 without also reducing another enzyme COX-1. The inhibition of COX-1 results in unwanted side effects, but Piroxicam cannot select between the two. There are NSAIDs available now that can reduce only COX-2 and they are considered more safe.

Storage Information

Store in a tightly sealed container at room temperature.

Missed Dose?

If you miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Piroxicam may result in these side effects:

  • Vomiting
  • Diarrhea
  • Liver problems
  • Lethargy
  • High Blood pressure
  • Fever
  • Allergic reaction (labored breathing, hives, etc)
  • Ulceration of the digestive tract

Piroxicam may react with these drugs:

  • Digoxin
  • Cisplatin
  • Furosemide
  • Diuretics
  • Methotrexate
  • Corticosteroids
  • Other NSAIDs
  • Anticoagulants
  • Other drugs that may cause ulceration of the digestive tract