5 Signs of Kidney Disease in Dogs

Jennifer Coates, DVM
By Jennifer Coates, DVM on Feb. 29, 2016
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Renal Disease – Acute versus Chronic

by Dr. Jennifer Coates


Renal (kidney) disease can be divided into two broad categories: acute and chronic. Acute renal disease develops over the course of days and usually has a single cause, such as antifreeze poisoning or a kidney infection. Chronic renal disease comes on much more slowly and is typically diagnosed in older dogs. It is the result of the gradual loss of kidney function. Most often, a cause is never identified.


The kidneys can’t regenerate themselves. When functional renal tissue is damaged beyond repair it is gone forever. The signs of renal disease start to become evident once two-thirds to three-quarters of kidney function has been lost.

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Changes in Urination

The kidneys play a vital role in keeping water where it is needed—inside the body. Producing large amounts of dilute urine is one of the first signs of renal disease in dogs. This can result in more frequent trips outside and accidents in the house.


On the other hand, dogs with severe acute renal disease often produce less urine than normal and as the condition progresses, may ultimately produce none at all. Their kidneys have completely shut down. 

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Increased Thirst

When water is being lost from the body in the form of large amounts of dilute urine, dogs with renal disease become dehydrated and thirsty. At the beginning, they can compensate by drinking more water, but eventually they can’t drink enough to replace what is being lost.

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Dehydration makes dogs feel bad. They lose energy and may simply want to rest rather than take part in the activities they used to love.


Healthy kidneys are also responsible for filtering waste products out of the bloodstream and putting them into urine to be eliminated from the body. Renal disease compromises this important kidney function, which results in increased blood levels of metabolic waste products like blood urea nitrogen and creatinine. This also makes dogs feel sick.


Finally, in cases of chronic renal disease, the kidneys no longer produce enough of the hormone (erythropoietin) that stimulates the bone marrow to produce red blood cells. The result is anemia and worsening lethargy.

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Poor Appetite

All of the metabolic changes that produce lethargy in dogs with renal disease can also make them feel bad enough that they lose their appetite. Dogs with chronic renal disease often have had a poor appetite for such a long time that they lose significant amounts of weight.


Dogs with renal disease are also at higher than average risk for developing gastrointestinal irritation and ulcers. These conditions cause nausea and abdominal pain (especially after a meal), making affected dogs even less likely to eat.

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Gastrointestinal Signs

Dogs with advancing renal disease will often start to vomit as a result of the irritation and/or develop ulcers within their gastrointestinal tract, along with other metabolic changes. Some dogs also develop diarrhea, but if dehydration becomes severe enough, constipation may result.

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Signs of Advanced Renal Disease

The kidneys are vital to normal body function. When a dog has advanced renal failure, the following symptoms may become evident:

  • sores in the mouth
  • reclusive behavior
  • sunken eyes from severe dehydration
  • difficulty/inability to stand or walk
  • crying out from discomfort
  • dementia
  • problems breathing
  • seizures
  • sudden collapse
  • bleeding 

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Don’t Wait to See Your Vet

As is the case with most serious canine diseases, the sooner dogs receive appropriate treatment for renal disease the better their prognosis. Some cases of acute renal disease can be cured, and these lucky dogs will go on to live happy, healthy, and, hopefully, long lives.


Chronic renal disease is not curable, but some cases can be managed in such a way that dogs enjoy an excellent quality of life for an extended period of time.


For more information, see Kidney Failure in Dogs and How to Treat Chronic Renal Failure in Dogs.