Intestinal Tumors (Apudomas) in Dogs

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Apudoma in Dogs

Apudoma is a gastrointestinal tumor found in dogs and cats which secretes peptide hormones -- hormones that play a role in regulating metabolism, growth, development, and tissue function. In the long run, the tumor(s) can cause ulcers, damage the esophagus because of chronic reflux, and damage the lining of the intestines.


  • Vomiting (sometimes with blood)
  • Weight loss
  • Loss of appetite (anorexia)
  • Diarrhea
  • Lethargy
  • Fever
  • Depression
  • Excessive thirst
  • Tarry-looking stools
  • Bloody stools (red blood)
  • Abdominal pain


The cause of apudoma is currently not known.


Your veterinarian will want to rule out the following diseases:

  • Kidney failure
  • Inflammatory gastritis
  • Stress-induced ulceration
  • Ulceration brought on by medication (e.g., anti-inflammatory drugs or steroids)
  • Uremia (condition which causes waste products to be retained in the blood)
  • Other conditions associated with hyperacidity in the digestive tract and ulceration

The veterinarian will then run blood tests and chemistry analysis to identify if the animal has iron-deficiency anemia as a result of the gastrointestinal bleeding. Other concerns may include inadequate protein in the blood stream and an imbalance in electrolytes, due to the excessive vomiting.

In addition, an ultrasound of the abdomen can be used to determine whether there is a tumor in the animal's pancreas, as well as an aspirate of any masses to test for mast cell disease. An endoscopy and biopsy of the upper digestive tract may also be recommended.


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