Mouth Cancer (Adenocarcinoma) in Dogs

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Salivary Gland Adenocarcinoma in Dogs

The salivary glands produce and secrete saliva to help in lubrication and improve the solubility of food, an essential component of the digestive process. There are four major salivary glands, including the mandibular, sublingual, parotid, and zygomatic gland. Adenocarcinoma can affect any of these salivary glands, but the most commonly affected gland in dogs is the mandibular gland.

Adenocarcinoma is characterized as originating in the glandular tissue, and like other carcinomas, can be especially malignant, spreading quickly throughout the body. This is generally a locally invasive tumor, but it can also metastasize and invade other distant parts and organs of the body. Like other adenocarcinomas, salivary gland adenocarcinoma is usually found in older animals, around 10-12 years of age.

Symptoms and Types

Symptoms of adenocarcinoma of the salivary glands depends upon the type of salivary gland that is affected. Following are a few of the common symptoms related to salivary gland adenocarcinoma:

  • Painless swelling of upper neck, ear base, or upper lip
  • Halitosis (foul breath)
  • Drooling
  • Weight loss
  • Poor appetite
  • Dysphagia (difficulty in swallowing)
  • Exophthalmos (bulging of eye)
  • Sneezing
  • Dysphonia (hoarseness)


The exact cause is still unknown.


Your veterinarian will perform a thorough physical exam on your pet, taking into account the background history of symptoms. Blood tests, biochemical profiles and urinalysis will be performed, though results will often return as normal with this disease. Radiographs of affected areas and bones can reveal important information about the nature and extent of the problem. X-rays of other regions may also be performed to see if the tumor has metastasized into these regions of the body, and more refined procedures, like tissue biopsy, will help in establishing a confirmatory diagnosis.

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