PetMD Seal

Metabolic Muscle Disease without Inflammation in Cats

2 min read

Non-inflammatory Metabolic Myopathy in Cats


Non-inflammatory metabolic myopathy is a rare muscle disease associated with metabolic disorders like various enzyme defects or storage of abnormal metabolic byproducts and others. Unfortunately, little is known about how the disorder affects cats exactly.


Symptoms and Types


  • Muscular weakness
  • Cramps
  • Exercise intolerance
  • Regurgitation and/or difficulty swallowing (dysphagia)
  • Collapse
  • Dark urine
  • Vomiting
  • Abdominal distention




  • Congenital (born with this problem) error in metabolism
  • Acquired (later in life) problems in metabolism
  • Viral infections
  • Drug exposure
  • Environmental factors




You will need to give a thorough history of your cat’s health, the onset and nature of the symptoms, to your veterinarian. He or she will then conduct a complete physical examination as well as a biochemistry profile, urinalysis, and complete blood count -- the results of which may show abnormalities related to metabolic problems involved. For example, the biochemistry profile may show abnormal levels of serum creatine (enzyme found in muscle, brain, and other tissues) and abnormally low levels of glucose (hypoglycemia).


Your veterinarian may also choose more enzyme assays and other specific testing to determine the cat's levels of amino acids, organic acids, and creatine. DNA-based tests, meanwhile, are used to identify specific carriers.


Often, a muscle tissue sample will be sent to a veterinary pathologist for further evaluation. This may reveal abnormal accumulation of fats or glycogen within muscle cells.




Related Articles

Kneecap Dislocation in Cats

Patellar luxation occurs when the cat's kneecap (patella) is dislocated from its normal anatomic position and is thought to be quite rare in...

Hereditary, Non-Inflammatory Muscular Disease in Cats

Muscular Dystrophy is an inherited, progressive, and non-inflammatory degenerative muscular disease caused by a deficiency of dystrophyin, a...

Joint Cartilage Erosion in Cats

Erosive, immune-mediated polyarthritis is an immune-mediated inflammatory disease of the joints, in which the cartilage of the cat's joint (articular...

Non-Inflammatory Hereditary Muscle Disease in Cats

Non-inflammatory hereditary myotonia is a muscle disease characterized by persistent contraction or delayed relaxation of muscles, especially...