PetMD Editorial
By PetMD Editorial
Published: July 18, 2014

Drug Info

  • Common Name: Anipryl
  • Generics: Anipryl
  • Drug Type: Monoamine Oxidase Inhibitor
  • Used For: Canine cognitive dysfunction syndrome or Cushing’s Disease
  • Species: Dogs
  • Administered: Oral
  • How Dispensed: Prescription Only
  • Available Forms: Tablets & Capsules
  • FDA Approved: Yes, for dogs


Selegiline is used for Canine cognitive dysfunction or Cushing’s Disease.

Dosage and Administration

Selegiline should be given according to your veterinarian’s instructions. 

Missed Dose?

If a dose of Selegiline is missed, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not give two doses at one time.

Possible Side Effects

Side effects from Selegiline could include but are not limited to:

  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Lethargy
  • Restlessness
  • Loss of hearing
  • Excessive Licking
  • Shivers/Shaking

Please contact your veterinarian immediately if you notice any side effects.


Do not give to animals that are allergic to Selegiline or to pregnant or lactating animals, as the safety of the drug not been determined in animals that are pregnant or lactating.

Appropriate diagnostic testing will need to be completed by your vet to confirm the diagnosis before starting therapy. Selegiline is not for use in dogs that have Cushing’s Disease caused by adrenal gland tumors or from the administration of corticosteroids.


Selegiline should be stored at room temperature. Store out of children’s reach.

Drug Interactions

When using Selegiline, please consult your veterinarian with any other medications you are currently giving your pet, including supplements, as interaction could occur. Interactions with amitraz (Mitaban), buspirone, ephedrine, meperidine, phenylpropanolamine (Proin), fluoxetine, tramadol, clomipramine and amitriptyline have been observed.

Signs of Toxicity/Overdose

Overdose of Selegiline may cause:

  • Decreased weight
  • Drooling
  • Decreased papillary response (pupils not getting smaller in bright light)
  • Panting
  • Dehydration
  • Behavior changes

If you suspect or know you dog has had an overdose, it could be fatal so please contact your veterinarian, an emergency vet clinic, or the Pet Poison Helpline at (855) 213-6680 immediately.

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