PetMD Editorial
By PetMD Editorial
Published: November 7, 2012

Drug Info

  • Common Name: Program®
  • Drug Type: Parasiticide
  • Used For: Treatment of fleas
  • Species: Dogs, Cats
  • Administered: Tablets, Injectable
  • How Dispensed: Prescription only
  • Available Forms: Monthly Tablet in 45 mg, 90 mg, 204.9 mg, & 409.8 mg, 6 month Injection for cats only
  • FDA Approved: Yes

General Description

Lufenuron is used to control flea infestations on pets. It inhibits the growth of flea larva and prevents them from becoming an adult insect. Lufenuron is not effective against adult fleas, but prevents growth of the infestation on your pet. These adult fleas will still be able to feed on your pet and cause itching and discomfort. Another drug, usually nitenpyram, will have to be used to kill the adult fleas.

Also, eggs that were laid prior to treatment with Lufenuron may take months to hatch, so it may take a few months for your pet to be completely free of fleas.

Lufenuron is found in a product called Program®, which is a tablet your dog or cat can take monthly. It also comes in an injectable form your veterinarian can give your cat every 6 months.

One preventative called Sentinel® mixes Lufenuron with Milbemycin, which is used to prevent heartworm and other parasitic infestations on your pet.

Lufeneron tablets are to be given every 30 days, preferably on the same day every month to treat and prevent fleas and other parasites.

Always give Lufenuron after a full meal to ensure adequate absorption.

How It Works

Lufenuron enters your pet’s bloodstream, and enters the female flea when she feeds on your pet’s blood. It halts egg production by preventing the flea larva inside the adult female from being able to make chitin, which makes them unable to produce an exoskeleton and grow.

Storage Information

Store at room temperature.

Missed Dose?

Give the dose as soon as possible. If it is almost time for the next dose or you have missed many doses, skip the missed ones and continue with the regular monthly schedule. Do not give your pet two doses at once. Notify your veterinarian that you missed a dose.

Side Effects and Drug Reactions

Lufeneron may result in these side effects:

  • Loss of appetite
  • Vomiting
  • Diarrhea
  • Lethargy
  • Itching
  • Difficulty breathing
  • Reddened skin
  • Temporary lump at injection site

Lufenuron does not appear to react with any other drugs.


Lufenuron is safe for use in pets over 6 weeks of age.

Please discuss the safety of Lufenuron with your veterinarian when concerning a pregnant or lactating pet.

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