Pancreatic Enzymes

PetMD Editorial
By PetMD Editorial on Mar. 20, 2013

Drug Info

  • Common Name: Viokase, Pancrezyme, Epizyme
  • Generics: No generics available
  • Drug Type: Pancreatic Enzyme
  • Used For: Pancreatitis
  • Species: Dogs, Cats
  • Administered: Powder and Tablets
  • How Dispensed: Prescription Only
  • Available Forms: Powder and Tablets
  • FDA Approved: Yes


Pancreatic Enzyme is used as a digestive aid: replacement therapy where digestion of protein, carbohydrate and fat is inadequate due to exocrine pancreatic insufficiency.

Dosage and Administration

Always follow the dosage instructions from your veterinarian.

Pancreatic Enzyme tablets are often given before each meal; the powder is usually added to moistened food.  Thorough mixing is recommended to ensure the enzymes come into close contact with the food particles.

Dosage and Administration

Dogs: 2-3 tablets or ¾ - 1 teaspoonful (2.8g/teaspoonful) with each meal.

Cats: ½ - 1 tablet or ¼ - ¾ teaspoonful (2.8g/teaspoonful) with each meal.

Missed Dose?

If a dose of Pancreatic Enzyme is missed, skip the dose and resume your regular schedule. Do not give two doses at one time.

Possible Side Effects

High doses of Pancreatic Enzyme may cause: 

  • Vomiting
  • Diarrhea or loose stool
  • Difficulty breathing
  • Irritation around the mouth
  • Hives
  • Swelling
  • Seizures
  • Pale gums
  • Cold limbs
  • Coma

Immediately contact your veterinarian if you think your dog has any medical problems or side effects while taking Pancreatic Enzyme.


If your pet has any allergic reactions to the medication please contact your veterinarian immediately. Be sure to let your veterinarian know of other medications your pet is on or may be taking as they may interact with the Pancreatic Enzyme.

Do not administer to pets that are allergic to pork products.


Store in a tight, light-resistant container at room temperature away from heat and direct sunlight.

Drug Interactions

Consult your veterinarian when giving other medications with Pancreatic Enzyme as interactions may occur.  Possible interactions may be noticed but not limited to antacids, H2 blockers, proton pump inhibitors, vitamins or supplements.

Signs of Toxicity/Overdose

Overdose of Pancreatic Enzyme may cause : 

  • Diarrhea
  • Vomiting
  • Cramping

If you suspect or know you dog has had an overdose, please contact your veterinarian or emergency vet clinic immediately.

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