Written by:

PetMD Editorial
Published: April 03, 2013

Drug Info

  • Drug Name: Marbofloxacin
  • Common Name: Marbofloxacin
  • Generics: Zeniquin
  • Drug Type: Antibiotic of the quinolone class
  • Used For: Treat bacterial infections
  • Species: Dogs, Cats
  • Administered: Tablets
  • How Dispensed: Prescription Only
  • Available Forms: 25mg, 50mg, 100mg, 200mg
  • FDA Approved: Yes


Marbofloxacin (Zeniquin) is indicated for the treatment of infections in dogs and cats associated with bacteria susceptible to marbofloxacin.

Dosage and Administration

Always follow the dosage instructions from your veterinarian. Be certain to use all medication that is prescribed; your pet may appear to be well but infection may recur or worsen if all medication is not administered.

Missed Dose?

If a dose of Marbofloxacin (Zeniquin) is missed, give it as soon as you remember. If you remember when it is almost time for the next dose, skip the one you missed and get back on your regular schedule. Do NOT double the dosing.

Possible Side Effects

Mild side effects that could occur include:

  • Loss of appetite
  • Vomiting
  • Decreased activity

Less likely but more severe side effects include: 

  • Seizures
  • Depression
  • Dizziness
  • Behavior changes

Immediately discontinue and contact your veterinarian if you think your dog has any medical problems or side effects while taking Marbofloxacin. Please be aware that other side effects may occur.


Do not administer to pets that are allergic to Marbofloxacin (Zeniquin). If your pet has any allergic reactions to the medication please contact your veterinarian immediately.

Do not use in pregnant, lactating or breeding animals. Do not use in animals with CNS (central nervous system) disorders, such as epilepsy, it could cause seizures.

Do not use in pets less than 12 months of age. Marbofloxacin may cause problems in the development of bone/joints of young growing animals.

Use caution when giving to pets that have liver or kidney disease.

Be sure you pet has access to clean drinking water while on marbofloxacin.

Human Precautions: People that are allergic to quinolone antibiotics, such as ciprofloxacin or levofloxacin, should not handle the medication; a photosensitivity reaction could occur with just contact.


Store below 86°F and keep out of children’s reach.

Drug Interactions

Consult your veterinarian when giving other medications with marbofloxacin as interactions may occur. Compounds containing divalent and trivalent cations can interfere with the absorption of quinolones.      

Signs of Toxicity/Overdose

Overdose of Marbofloxacin may cause: 

  • ·         Lack/Loss of appetite
  • ·         Vomiting
  • ·         Diarrhea
  • ·         Dizziness
  • ·         Dilated pupils or blindness (in cats)
  • ·         Seizures

If you suspect or know you dog has had an overdose, please contact your veterinarian or emergency vet clinic immediately.