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Drug Info

  • Drug Name: Cefpodoxime Proxetil
  • Common Name: Simplcef
  • Generics: Cefpodoxime Proxetil
  • Drug Type: Cephalosporin
  • Used For: Antibiotic used for a wide variety of infections
  • Species: Dogs, Cats
  • Administered: Tablets
  • How Dispensed: Prescription Only
  • Available Forms: 100mg & 200mg
  • FDA Approved: Yes


Cefpodoxime Proxetil is used for treatment of infections, most commonly skin infections caused by susceptible strains of Staphylococcus intermedius, aureus and canis, E. coli, Pasteurella multocida, and Proteus mirabilis bacteria. 

Dosage and Administration

Always follow the dosage instructions from your veterinarian and any special instructions they may provide you. Cefpodoxime Proxetil can be given with our without food.

Ensure entire course of treatment is administered so the infection does not recur or worsen.

Missed Dose?

If a dose of Cefpodoxime Proxetil is missed, give it as soon as you remember. If the dose is close to the next dose, skip the dose you missed and resume your regular schedule. Do not give two doses at one time.

Possible Side Effects

Side effects are rare but may include:

  • Lack of Appetite
  • Vomiting
  • Diarrhea

Dogs may also experience drooling, rashes and excitability, while cats may also experience vomiting, rashes and a fever greater than 103 degrees Fahrenheit. Contact your veterinarian if you think your pet has any medical problems or side effects while taking Cefpodoxime Proxetil.


Do not administer to pets that are allergic to cephalosporins or penicillins unless directed by your veterinarian and do not use in pregnant or lactating dogs. Use caution when giving to pets with seizures, epilepsy, or kidney disease and if your pet has any allergic reactions to the medication, contact your veterinarian immediately.

Human Precautions

People that are allergic to cephalosporin or penicillin antibiotics should not handle Cefpodoxime Proxetil as allergic reaction may occur.


Store at room temperature between 68-77oF.  Be sure to replace cap securely after each opening.

Keep out of children’s reach.

Drug Interactions

Consult your veterinarian when giving other medications or supplements with Cefpodoxime Proxetil as interactions may occur. If your pet is on any aminoglycosides (gentamicin or neomycin) or blood thinners, interactions may occur. Cefpodoxime Proxetil may cause blood levels to increase if used with probenicid, a medication which treats chronic gout and gouty arthritis.

Signs of Toxicity/Overdose

Overdose of Cefpodoxime Proxetil may cause:

  • Vomiting
  • Diarrhea
  • Jaundice
  • Bruising easily

If you suspect or know you dog has had an overdose, please contact your veterinarian, an emergency vet clinic, or the Pet Poison Helpline at (855) 213-6680 immediately. After an overdose, your pet should also be re-evaluated before Lactated Ringer’s Injections are continued.

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