PetMD Seal

Skin Bumps (Granulomatous Dermatoses) in Cats

3 min read

Sterile Nodular/Granulomatous Dermatoses in Cats


Sterile nodular/granulomatous dermatoses are diseases in which the primary lesions or masses of tissue, are solid, elevated, and greater than one centimeter in diameter. These nodules are usually the result of an infiltration of inflammatory cells into the skin and be a reaction to interal or external stimuli.


Symptoms and Types


  • Nodular dermatofibrosis
  • Calcinosis circumscripta
  • Malignant histiocytosis




  • Amyloidosis (a waxy protein deposit, or amyloid, in the body)
  • Reaction to foreign body
  • Spherulocytosis (disease of red blood cells)
  • Idiopathic sterile granuloma and pyogranuloma
  • Calcinosis circumscripta (skin stones, similar to calcinosis cutis)
  • Malignant histiocytosis (abnormally spreading immune-type cells)
  • Cutaneous histiocytosis (immune-type cells spreading to skin)
  • Sterile panniculitis (inflammation of the skin)
  • Nodular dermatofibrosis (bumps filled with excess elastic skin material which accompanies kidney disease)
  • Cutaneous xanthoma (a benign skin problem, involving immune cell infiltration usually accompanies hyperlipoproteinemia or diabetes mellitus)




Your veterinarian will perform a thorough physical exam on your cat, with a blood chemical profile, a complete blood count, an electrolyte panel and a urinalysis. You will need to provide a thorough history of your cat's health leading up to the onset of symptoms.


The physical exam should include a dermatologic exam, during which skin biopsies for histopathology can be taken to determine if structural changes have occurred in the tissue. Skin scrapings will also be examined microscopically and cultured for bacteria, mycobacteria and fungi.




Related Articles

Wart Virus in Cats

The term papillomatosis is used to describe a benign tumor on the surface of the skin. Caused by a virus known as the papillomavirus, the growth...

Fatty Layer or Nodule Under the Skin in Cats

Panniculitis is a condition where the layer of fat just under the cat's skin (subcutaneous fat tissue) becomes inflamed.

Twitch-Skin Syndrome in Cats

Feline hyperesthesia syndrome (FHS), also known as “twitch-skin syndrome” and “psychomotor epilepsy,” is an obscure cat disorder resulting in...

Scaly Skin in Cats

The term exfoliative denotes the detachment and shedding of surface skin cells, whereas dermatosis refers to any skin abnormality or disorder....