PetMD Editorial
By PetMD Editorial on Nov. 7, 2012

Drug Info

  • Common Name: Rifadin®, Rimactane®
  • Drug Type: Antibiotic
  • Used For: Bacteria, Fungi
  • Species: Dogs, Cats
  • Administered: Capsules, Injectable
  • How Dispensed: Prescription only
  • Available Forms: Rifadin® 600mg powder for injection, Rifadin® 150mg and 300mg capsules, Rimactane® 150mg and 300mg capsules
  • FDA Approved: No

General Description

Rifampin is used to treat many bacterial infections of Rhodococcus, Mycobacteria and Staphylococci, as well as some antifungal activity against histoplasmosis or aspergillosis. It is commonly used in conjunction with another antibiotic or antifungal.

How It Works

Rifampin is very effective at entering abcesses and other tissues including those of the central nervous system and bones. Once it encounters a bacteria, it inhibits protein synthesis by binding to RNA polymerase and preventing RNA transcription.

Storage Information

Store in a tightly sealed container at room temperature.

Missed Dose?

If you miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Rifampin may result in these side effects:

  • Red/orange urine
  • Rash
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • Anemia

Rifampin may react with these drugs:

  • Anticoagulants
  • Barbiturates
  • Benzodiazepine
  • Corticosteroids
  • Chloramphenicol
  • Dapsone
  • Ketoconazole
  • Propranolol
  • Quinidine

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PREGNANT PETS - Use of Rifampin in pregnant pets has not been extensively researched.


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