Cytoxan

PetMD Editorial
November 07, 2012
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General Description

Cyclophosphamide is used in the treatment of cancers, including lymphoma, and a number of immune-mediated diseases. It is an immunosuppressant that kills rapidly dividing cells.

How It Works

Cyclophosphamide binds to DNA, interferring with normal cell function. It specifically targets the rapidly replicating DNA in rapidly dividing cells such as cancer cells or inflammatory cells.

 

Storage Information

Injectable may need to be refrigerated - pay close attention to the drug label’s instructions for storage information.

Missed Dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Cyclophosphamide may result in these side effects:

  • Loss of appetite
  • Bone marrow suppression
  • Upset stomach
  • Development of Hemorrhagic Cystitis as displayed by blood in the urine

Cyclophosphamide may react with these drugs:

  • Barbiturates
  • Bone marrow suppressants
  • Thiazide diuretics
  • Allopurinol
  • Digoxin
  • Doxorubicin
  • Phenobarbital
  • Succinylcholine chloride

ALWAYS WEAR GLOVES WHEN HANDLING THIS DRUG - THIS IS A CYTOTOXIC DRUG

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH LIVER OR KIDNEY DISEASE

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PREGNANT PETS - It is toxic to unborn fetuses due to their quickly dividing cells. Use only when the benefits outweigh the risks.