Skin Reactions to Drugs in Dogs

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Cutaneous Drug Eruptions in Dogs

Cutaneous drug eruptions cover a spectrum of diseases and clinical signs. They can vary markedly in clinical appearance and pathophysiology – the functional change that accompanies the disease. It is likely that many mild drug reactions go unnoticed or unreported; thus, incidence rates for specific drugs are unknown and most of the facts available on drug-specific reactions have been extrapolated from reports in the human literature.

Some types of drug reactions appear to have a familial basis.

Symptoms and Types

  • Itchiness, scratching excessively
  • Flat, small red patches and raised bumps
  • Exfoliative erythroderma, a condition where at least 50 percent of the skin's body surface area turns bright red and scaly
  • Scales
  • Hives
  • Allergy symptoms
  • Skin redness and swelling
  • Patches of darker skin or plaques (round patches) that expand and may clear in the center, producing a bull’s-eye appearance
  • Blistering skin due to drug-induced pemphigus/pemphigoid (a rare autoimmune disorder of the skin)


  • Drugs of any type
  • Exfoliative erythroderma (peeling redness):
    • Most often associated with shampoos and dips
    • Commonly seen with reactions to topical ear medications, usually in the ear canals and on concave pinnae (outer part of the ear)
  • Can occur after the first dose of the drug, or after weeks to months of administration of the same drug due to sensitization (when the body becomes hypersensitive after repeated exposure to a material)


Your veterinarian will perform a complete physical exam on your dog. The exam will include a full dermatologic exam, with skin scrapings for lab culturing in order to rule out or confirm bacterial and fungal infections. A skin biopsy may also be indicated. Your veterinarian will also order a blood chemical profile, a complete blood count, an electrolyte panel and a urinalysis. will need to give a thorough history of your dog's health, onset of symptoms, and possible incidents that might have precipitated this condition. history you provide may give your veterinarian clues as to what is causing the skin reaction and whether the problem needs to be treated on a deeper level or is only an external condition.

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