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Skin and Eye Inflammation Due to Autoimmune Disorder (Uveodermatologic Syndrome) in Dogs

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Uveodermatologic Syndrome in Dogs


Your dog's immune system produces chemicals called antibodies to protect its body against harmful substances and organisms such as viruses, bacteria, etc. An autoimmune disorder is a condition in which the immune system cannot tell the difference between harmful antigens and its own healthy body tissues, leading it to destroy the healthy body tissues. Uveodermatologic syndrome is one such autoimmune disorder known to affect dogs.


Some breeds are at an increased risk of developing this disorder, including Akitas, Samoyeds, and Siberian huskies. However, dogs of all ages are at risk.


Symptoms and Types


  • Inflammation of the interior of the eye (uvea)
  • Loss of skin pigmentation (leukoderma) in the nose, lips, eyelids, footpads, scrotum, anus, and hard palate




Underlying autoimmune disorder




After recording a complete history, your veterinarian will perform a thorough physical and ophthalmological exam on your dog, taking into account the background history of symptoms and possible incidents that might have led to this condition. Standard laboratory work will include a blood chemical profile, a complete blood count, a urinalysis and an electrolyte panel. The results of these tests are often found normal in animals with this disorder.


Your veterinarian will also take skin tissue samples to be sent to laboratory for evaluation. The veterinary pathologist will examine the tissue sample microscopically to distinguish any changes that are characteristic of this condition.




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