PetMD Seal

Kidney Toxicity (Drug-Induced) in Cats

2 min read

Drug-Induced Nephrotoxicity in Cats


Certain medications administered for the purpose of diagnosing or treating medical disorders may cause kidney damage. When this occurs, it is referred to as drug-induced nephrotoxicity. It is more commonly recognized in dogs than cats. And although drug-induced nephrotoxicity may occur in cats of any age, older cats are more susceptible.


Symptoms and Types


Signs associated with nephrotoxicity may include:





Nephrotoxicosis can be induced by the administration of pharmacologic agents (or drugs), which interfere with the blood flow to the kidneys as well as cause tubular dysfunction in the kidneys. If left untreated, the damage to the renal tubule cells may lead to tubular necrosis and even kidney failure. Risk factors that may increase the odds of developing drug-induced nephrotoxicity include dehydration, advanced age, and fever.




When drug-induced nephrotoxicity is suspected, a veterinarian will often biopsy a portion of kidney tissue. This will help him or her identify kidney failure and also the proper course of treatment. Another useful diagnostic procedure is a urine analysis.




Related Articles

Kidney Enlargement in Cats

Renomegaly is a condition in which one or both kidneys are abnormally large, confirmed by abdominal palpation, ultrasounds, or X-rays. Learn...

Pus in the Urine in Cats

Pyuria is a medical condition that can be associated with any pathologic process (infectious or noninfectious) that causes cellular injury or...

Excess Acidity in the Blood of Cats

Renal tubular acidosis (RTA) is a rare syndrome that causes the kidney to be unable to excrete acid through the urine, leading to extreme acidity...

Fluid Buildup in the Kidney Due to Kidney or Ureter Obstruction in Cats

In most cats, hydronephrosis occurs when fluid builds up in the kidney, causing progressive distention of the renal pelvis (the funnel-like dilated...