Polysulfated Glycosaminoglycan

PetMD Editorial
By PetMD Editorial
Published: March 20, 2013

Drug Info

  • Common Name: Adequan
  • Generics: No generics available
  • Drug Type: PSGAG (Cartilage Protective Agent)
  • Used For: Degenerative Joint Disease (a form of joint inflammation or arthritis)
  • Species: Dogs
  • Administered: Injectable
  • How Dispensed: Prescription Only
  • Available Forms: 100mg/mL & 250mg/mL concentrations
  • FDA Approved: Yes


Polysulfated Glycosaminoglycan, injectable is an osteoarthritis medication that is used to treat traumatic and non-infectious abnormalities and arthritis associated with joint stiffness and limping.

Dosage and Administration

Polysulfated Glycosaminoglycan, injectable should be given according to your veterinarian’s instructions. 

The medication is given by IM (intramuscular injection). Your veterinarian may also inject the PSGAG directly into the joint (intra-articular).

Missed Dose?

If a dose of Polysulfated Glycosaminoglycan is missed, give it as soon as you remember.  If you remember when it is almost time for the next dose, skip the one you missed and get back on your regular schedule. Do NOT double the dosing.

Possible Side Effects

Side effects associated with intramuscular injection are few; injections directly to the joints may cause: 

  • Joint Pain
  • Swelling
  • Lameness

Other side effects include decreased ability for blood to clot. Signs of this include:

  • Bleeding from the nose
  • Blood in the stool
  • Dark and tarry stools

If you think your animal has any medical problems or side effects while taking Polysulfated Glycosaminoglycan (Adequan) please consult your veterinarian. 


Do not mix this medication with any other drugs or chemicals. Do not use in animals that are hypersensitive to this medication or are suspected to have a bleeding disorder.

This medication's manufacturer does not recommend using it on breeding, pregnant, or lactating animals.


Polysulfated Glycosaminoglycan should be stored at room temperatures between 64-77oF.

Drug Interactions

Consult your veterinarian when giving other medications, including non-steroidal anti-inflammatory drugs (NSAIDs), such as Carprofen, deracoxib, etodolac, aspirin, meloxicam, or any drugs that may affect blood clotting such as heparin or warfarin. You should also consult your veterinarian if your animal is taking any supplements or vitamins.

Signs of Toxicity/Overdose

Overdose of Polysulfated Glycosaminoglycan (Adequan) is rare but could cause: 

  • Joint Pain
  • Swelling
  • Lameness

If you suspect or know your animal has had an overdose, please contact your veterinarian or emergency vet clinic immediately.

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