Diabetes Mellitus Without Complication in Cats
Diabetes is a disorder of carbohydrate, protein, and fat metabolism caused by an absolute or relative insulin deficiency. Metabolism refers to how the body digests and uses food for growth and energy, and this process is largely dependent on a sufficient amount of insulin in the body.
Insulin is a hormone that is produced in the pancreas, releasing into the cells in response to the digestive conversion of proteins into glucose in the bloodstream. Much of the food that is ingested is broken down into glucose, a type of sugar in the blood and one of the body's main sources of energy. Appropriate insulin function will trigger the liver and muscles to take up glucose from the blood cells, converting it to energy.
In diabetes, there might be an absolute shortage of insulin (Type I), or the cells may not be responding appropriately to the insulin, a condition termed insulin resistance (Type II). Both of these conditions will prevent the muscles and organs from converting glucose to energy, and will result in excessive amounts of glucose in the blood. Excessive blood sugar is also referred to as hyperglycemia.
Diabetes, a common condition for humans, is also relatively common in domestic animals like cats. Type I diabetes is the more severe form of the disease, and is dependent on insulin injections for maintaining blood sugar balance (insulin dependent diabetes mellitus – IDDM).
In cats, Type II diabetes, a non-insulin dependent diabetes mellitus (NIDDM), is the more common form to be diagnosed, but eventually, almost all cats that are diagnosed with diabetes, in either form, will need injections of insulin to keep the blood sugar balanced. An estimated one in 1200 cats will develop diabetes during its life-span. At heightened risk are obese cats and male cats. Most cases are seen in cats middle aged and older, but it can occur at any age.
Symptoms and Types
- Excessive thirst
- Excessive urination (increase in both frequency and amount of urine)
- Poor appetite
- Weight loss
- Wasting of back muscles
- Weakness in back legs
- Oily coat with dandruff
- Enlarged liver
- Ketoacidosis – metabolic acidosis caused by the breakdown of fat and proteins in the liver in response to insulin deficiency
- Genetic susceptibility for some – usually Type I in younger cats
- Inflammation of the pancreas (pancreatitis)
- Occurs concurrently with certain diseases:
- Cushing's Disease
- Use of certain drugs
Your veterinarian will take detailed medical history from you of your cat's health leading up to the onset of symptoms and details of the exact symptoms. Standard tests will include a complete blood count, chemical profile, and urinalysis. These tests should be sufficient for diagnosis and initial treatment.
Typically, with diabetes, an unusually high concentration of glucose will be found in the blood and urine. Abnormally high levels of liver enzymes and electrolytes imbalances are also common. Urine test results may also show evidence of abnormally high levels of ketone bodies - water-soluble compounds produced as a by-product of fatty acid metabolism in the liver and kidney. A numbers of other abnormalities may also be found.
Radiographic studies, including x-rays and ultrasonography, can be helpful for the diagnosis of concurrent diseases and complications due to diabetes. Abdominal X-rays and ultrasound will help to determine the presence of kidney stones and/or inflammation of the pancreas and liver, as well as other associated abnormalities. In the case of liver disease, should it appear suspect, your veterinarian may decide to take a sample of liver tissue for further diagnostic evaluation.
A gland that aids in both digestive and insulin functions
An in-depth examination of the properties of urine; used to determine the presence or absence of illness
The product of metabolism of fat; may also be referred to as bodies of ketone or ketone bodies
A medical condition in which the pancreas becomes inflamed
A hormone created by the pancreas that helps to regulate the flow of glucose
Any product that is derived from but less in value than another product from the same source.
Elevated levels of glucose in the blood
Low amounts of glucose in the blood
A condition of the body in which pH levels are abnormally low.