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Spermatocele and Sperm Granuloma in Cats

Cyst epididymis, or sperm granuloma, is a condition in which a cyst has grown in the epididymis (part of the spermatic duct system), resulting in swelling of the duct or ducts. A spermatocele, meanwhile, is a cyst in the ducts or epididymis that conduct sperm, and is usually associated with a blockage. When sperm escape from these ducts into the surrounding tissue, chronic inflammation occurs. This becomes clinically important when bilateral (both sides) obstruction of the duct system leads to no live sperm in the seminal fluid. 

Symptoms and Types

It is suspected in cats that have no live sperm yet have normal-sized testes. In addition, it is rarely associated with pain or visible or palpable lesions.

Causes

• Trauma causing a break in the epididymal duct, where sperm are transported, stored, and matured, which releases sperm antigens into the surrounding tissue
• Adenomyosis - invasion of the epithelial lining cells of the epididymis into the muscular layers may be a factor; it is associated with excess estrogen production
• Overproliferation of cells of the epididymis may be a precursor of adenomyosis
• Complication of vasectomy or partial neuter, especially when surgical technique was not meticulous
• Congenital occlusion (blockage) of the epididymal duct (i.e., the cat was born with this disorder)

Diagnosis

In making a determination about why your cat’s sperm is deficient, your veterinarian will look at several possibilities, such a testicular degeneration, underdevelopment of the organs, insufficient ejaculation, and incomplete ejaculation. A physical examination will be conducted to look for pain or lesions in the reproductive organs. A urinalysis and possibly a blood test will also be standard for laboratory analysis. It may also be necessary to conduct a surgical testicular biopsy and a biopsy of affected the epididymal tissue to differentiate a benign from a malignant mass.