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Von Willebrand's Disease in Cats

VWF is an autosomal (non-sex-linked) trait, which both males and females express and transmit genetically and with equal frequency.

Von Willebrand’s disease (vWD) is a blood disease caused by a deficiency of von Willebrand Factor (vWF), an adhesive glycoprotein in the blood required for normal platelet binding (i.e., clotting) at the sites of small blood vessel injuries. In addition, vWF is a carrier protein for coagulation Factor VIII (necessary for blood to clot). A lack of vWF impairs platelet stickiness and clumping. Similar to hemophilia in humans, this condition can lead to excessive bleeding following an injury, due to the lack of clotting. The expression pattern of the severe forms (Types 2 and 3 vWD) is recessive while the milder form (Type 1 vWD) appears to be recessive or incompletely dominant.

This clotting disorder is rare in cats.

Symptoms and Types

• Spontaneous hemorrhage from mucosal surfaces:
  • Nosebleeds
  • Blood in the feces (black or bright red blood)
  • Bloody urine
  • Bleeding from the gums
  • Bleeding from the vagina(excessively)
• Bruising of skin
• Prolonged bleeding after surgery or trauma
• Blood loss anemia if there is prolonged bleeding

Causes

• Hereditary vWD is caused by mutations that impair vWF synthesis, release, or stability.

Diagnosis

Your veterinarian will perform a thorough physical exam on your cat, taking into account the background history of your cat's health and onset of symptoms. A blood chemical profile will be performed, with a complete blood count, a urinalysis, and an electrolyte panel. If there has been blood loss, a regenerative anemia will be seen on the complete blood count. Typically, the platelet count will be normal (unless your cat has experienced recent, massive bleeding), and coagulation tests will show normal results.

A clinical diagnosis of von Willebrand disease is based on a specific measurement of plasma vWF concentration bound to the antigen (vWF:Ag). The length of time that it takes for platelets to plug a small injury will be measured, with a test called the buccal mucosa bleeding time (BMBT). The BMBT test, along with the platelet function analyzer (PFA 100), are point-of-care screening tests where the endpoints are prolonged in patients with platelet clumping defects and vWF deficiency. Prolongation is nonspecific, and may accompany numerous severe disorders of the blood.