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Acute hepatic failure is a condition characterized by the sudden loss of 70 percent or more of the liver's function due to sudden, massive, hepatic necrosis (tissue death in the liver).
Primary and secondary hepatobiliary disorders - those dealing with the liver, gallbladder, bile ducts or bile - are generally associated with variable hepatic necrosis. However, acute liver failure from severe hepatic necrosis is an uncommon phenomenon. Acute liver failure can affect the body through a number of system failures:
Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat. Necrosis (tissue death) sets in, with loss of liver enzymes and impaired liver function ultimately leading to complete organ failure.
Acute liver failure also occurs due to extensive metabolic disorders in protein synthesis (albumin, transport protein, procoagulant and anticoagulant protein factors), and glucose absorption, as well as abnormalities in the metabolic detoxification process. If this condition is not treated promptly, it can result in death.
Acute liver failure is diagnosed through a full blood workup (hematology), biochemistry analysis, urine analysis, biopsy (the removal and analysis of affected tissue), and ultrasound or radiology imaging.
Hematology/biochemistry/urine analyses will test for:
Lab Tests will be used to look for:
Imaging tests will look for:
Hospitalization is vital for treating acute liver failure. Fluids and electrolytes, along with colloid (the gelatinous substance necessary for proper thyroid functioning) replacements and oxygen supplementation, are key aspects of treatment and care. Your dog will be placed on restricted activity in order to give the liver an opportunity to regenerate. Catheter feeding is recommended for highly unstable patients, while enteric feeding (feeding directly into the intestines) in small amounts is recommended for otherwise stable patients. A normal protein diet with supplemental vitamins E and K is advised.
The common medications used for liver failure are antiemetics, drugs for hepatic encephalopathy (brain disease, with or without edema), hepatoprotectants (to decrease the activity of aminotransferases), coagulopathy drugs, and antioxidants.
Vaccinating dogs against the infectious canine hepatitis virus (an acute liver infection), and avoiding the use of drugs that have potentially harmful hepatotoxins as ingredients can act as preventives against acute liver failure.
Less oxygen than normal in the blood
A condition in which the skin becomes yellow in color as do the mucous membranes; this is due to excess amounts of bilirubin.
A condition in which the liver becomes inflamed
Referring to the liver
The removal and destruction of red blood cells
Anything pertaining to the blood vessel system in the body
A condition of dead tissue
The product of protein being metabolized; can be found in blood or urine.
The study of the internal structures of the body as pertaining to ionizing radiation
The flow of blood through bodily tissue
The study of the causes and development of disease
The protein that moves oxygen in the blood
Appearing like particles or small granules in texture
A certain pigment that is produced when hemoglobin is destroyed.
The process of removing tissue to examine it, usually for medical reasons.
The fluid created by the liver that helps food in the stomach to be digested.
Term used to refer to any drug that is used to slow down or stop the clotting of blood for medical purposes.
A type of protein that can be dissolved in water; found in milk, egg white, certain muscle, blood, and some urine.
A passage in the body with walls
The collection of fluid in the tissue
Term used to imply that a situation or condition is more severe than usual; also used to refer to a disease having run a short course or come on suddenly.
A substance that causes chemical change to another
A disease of the brain of any type
Passing stool with blood in it