Hi stranger! Signing up for MypetMD is easy, free and puts the most relevant content at your fingertips.

Get Instant Access To

  • 24/7 alerts for pet-related recalls

  • Your own library of articles, blogs, and favorite pet names

  • Tools designed to keep your pets happy and healthy



or Connect with Facebook

By joining petMD, you agree to the Privacy Policy.

PetMD Seal

Clotting Deficiency (Liver Related) in Dogs

ADVERTISEMENT

Coagulopathy of Liver Disease in Dogs 

 

The liver is the primary site of synthesis of coagulation, anticoagulant, and fibrinolytic proteins. In fact, only five blood clotting factors are not produced there. Therefore, liver diseases that cause clotting issues in dogs can be very serious and sometimes life-threatening.

 

Symptoms and Types

 

  • Black feces due to digested blood (melena)
  • Bright red blood in the feces (hematochezia)
  • Vomiting or spitting up blood (hematemesis)
  • Prolonged bleeding after drawing blood, urine, or from recent surgical wounds
  • Spontaneous bruising (rare)

 

Causes

 

The causes of coagulopathy of liver disease are abundant, including:

 

  • Severe liver failure
  • Acute viral liver disease
  • Cirrhosis (hardening and shrinking of the liver with loss of functional tissue)
  • Extrahepatic bile duct obstruction (EHBDO)
  • Vitamin K deficiency linked to severe intra- or extrahepatic cholestasis (blockage of the bile ducts) or steatorrhea (fat in the feces due to trouble digesting fat since enzymes the liver makes are lacking).
  • Portosystemic Vascular Anomaly (PSVA), causing insufficient blood flow to the liver

 

Diagnosis

 

You will need to give a thorough history of your dog’s health, including the onset and nature of the symptoms, to the veterinarian. He or she will then perform a complete physical examination as well a biochemistry profile, urinalysis, complete blood count (CBC), and electrolyte panel.

 

Hemostatic tests like prolonged activated partial thromboplastin time (APTT), activated clotting time (ACT), prothrombin time (PT), thrombin clotting time (TCT), and Proteins invoked by Vitamin K Absence (PIVKA) are useful for measuring the severity of the dog’s inability to clot normally. Tests can also be performed to detect low coagulation/anticoagulant factor (antithrombin (AT) and protein (C) activity. X-rays, meanwhile, are used to identify liver abnormalities, fluid in the abdomen, abnormal intestinal motility and thickening in affected areas.

 

 

 

 

Related Articles

Clotting Deficiency (Inherited) in Dogs
The process of coagulation takes place when blood transforms from a free flowing...
READ MORE
Blood in the Chest in Dogs
Hemothorax is a condition that may occur suddenly (acute) or over a long period of...
READ MORE
Heat Stroke and Hyperthermia in Dogs
Hyperthermia is an elevation in body temperature that is above the generally accepted...
READ MORE
  • Lifetime Credits:
  • Today's Credits:
Hurry Before All Seats are Taken!
Enroll
Be an A++ Pet Parent! Take fun & free courses to earn badges & certifications. Choose a course»
Search dog Articles

 

Latest In Dog Nutrition

Does My Senior Dog Need Special Dog Food?
Whether or not your senior dog needs special dog food depends, to a large extent,...
READ MORE
5 Reasons Life Stage Diets Help Improve Pet ...
Balanced and complete nutrition is important for any animal. However, the nutritional...
READ MORE
Five Life-Lengthening Health Tips for Your ...
Anyone who has ever had a dog or cat wishes just one thing — that he or she has a...
READ MORE
Around the Web
MORE FROM PETMD.COM