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Juvenile Fibrosing Liver Disease in Dogs

Juvenile fibrosing liver disease is a noninflammatory liver disease which causes excessive extracellular matrix proteins to deposit in the liver tissue (also known as liver firbosis). It is typically seen in young or juvenile dogs, especially large breeds. If left untreated, a dog with this disease may develop cirrhosis and liver failure.

Although the cause to the fibrosis remains uncertain, chronic exposure to toxic bile, exposure to intestinal toxins, and liver injuries may be a factor.

Symptoms and Types

• Vomiting
• Diarrhea
• Blood in stool
• Loss of appetite (anorexia)
• Distended abdomen (ascites)
• Stunted growth, poor body condition
• Increased frequency and volume of urine (polyuria)
• Increased thirst (polydipsia) and consumption of water
• Stone formation in kidney, bladder, or urethra
• Nervous symptoms may be seen due to hepatic encephalopathy

Causes

Juvenile fibrosing liver disease is often associated with chronic exposure to gastrointestinal toxins. However, it may also relate to hemorrhagic gastrointestinal illnesses (portal endotoxemia) in young dogs.

Diagnosis

You will need to give a thorough history of your dog’s health to your veterinarian, including the onset and nature of the symptoms. He or she will then perform a complete physical examination as well as a complete blood count, biochemistry profile, and urinalysis. In some dogs, liver enzyme levels are found to be abnormally high in biochemistry panels, while the urinalysis may reveal the presence of ammonium bicarbonate crystals in the urine.

Abdominal ultrasonography will help in determining the structure and size of liver, but a liver biopsy may be required for detailed analysis of the liver tissue. If right-sided heart disease is suspected, your veterinarian may recommend performing echocardiography. Your veterinarian may also take a sample of the dog's abdominal fluid for further analysis, or conduct routine coagulation tests to rule out blood coagulation disorders.