Acute Hepatic Failure in Dogs

Acute hepatic failure is a condition characterized by the sudden loss of 70 percent or more of the liver's function due to sudden, massive, hepatic necrosis (tissue death in the liver).

Symptoms

Primary and secondary hepatobiliary disorders - those dealing with the liver, gallbladder, bile ducts or bile - are generally associated with variable hepatic necrosis. However, acute liver failure from severe hepatic necrosis is an uncommon phenomenon. Acute liver failure can affect the body through a number of system failures:

• Gastrointestinal: vomiting, diarrhea, blood in the stool (hematochezia)
• Nervous system: hepatic encephalopathy (brain disease related to liver failure)
• Hepatobiliary: the liver plus the gallbladder; jaundice, necrosis (tissue death) of the liver cells and bile duct cells
• Renal: the tubules of the kidney may be injured from toxins/metabolites
• Immune/Lymphatic/Hemic: imbalances in the blood and lymphatic systems, may lead to coagulant (clotting) complications

Causes

Acute liver failure is most often caused by infectious agents or toxins, poor flow of fluids into the liver and surrounding tissues (perfusion), hypoxia (inability to breathe), drugs or chemicals that are destructive to the liver (hepatotoxic), and excess exposure to heat. Necrosis (tissue death) sets in, with loss of liver enzymes and impaired liver function ultimately leading to complete organ failure.

Acute liver failure also occurs due to extensive metabolic disorders in protein synthesis (albumin, transport protein, procoagulant and anticoagulant protein factors), and glucose absorption, as well as abnormalities in the metabolic detoxification process. If this condition is not treated promptly, it can result in death.

Diagnosis

Acute liver failure is diagnosed through a full blood workup (hematology), biochemistry analysis, urine analysis, biopsy (the removal and analysis of affected tissue), and ultrasound or radiology imaging.

Hematology/biochemistry/urine analyses will test for:

• Anemia
• Irregularities in thrombocytes (clot promoting blood platelets)
• Abnormally high liver enzyme activity, or liver enzymes spilling out into the bloodstream, signaling liver damage – tests will look for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes in the bloodstream, as well as an increase in alkaline phosphatase (ALP), and declining levels of aminotransferases (enzymes that cause the chemical change of nitrogen carrying amino)
• Impairment of protein synthesis
• Low blood sugar
• Normal to low blood urea nitrogen (BUN) concentration (i.e., nitrogen level in the urine)
• The presence of bilirubin in the urine – the red-yellow bile pigment that is a degraded product of the deep red, nonprotein pigment in hemoglobin (the oxygen carrying pigment in red blood cells)
• The presence of ammonium urate crystals in the urine
• The presence of sugar and granular casts (solid deposits) in the urine, indicating internal tubular injury from drug toxicity, such as the drug induced toxicity that affects some dogs being treated with pain relievers (also known as non-steroidal anti-inflammatory drugs [NSAIDS])

Lab Tests will be used to look for:

• High values of total serum bile acid (TSBA) concentrations, which will indicate liver insufficiency. However, if non-hemolytic (not destructive to blood cells) jaundice has already been confirmed, TSBA findings will lose their significance in relation to acute liver failure
• High plasma ammonia concentration; this, in conjunction with high TSBA concentrations, would be strongly indicative of hepatic insufficiency
• Abnormalities in blood platelets and coagulation (blood clotting) factors
• Tissue necrosis and cell pathology; biopsy (tissue sample) results will confirm or negate zonal involvements, and identify any existent underlying conditions

Imaging tests will look for:

• X-rays and ultrasound tests may indicate an enlarged liver, and other hepatic abnormalities, including conditions that may not be directly related to the liver.