Arthritis of Multiple Joints in Dogs
Nonerosive, Immune-Mediated Polyarthritis in Dogs
Nonerosive immune-mediated polyarthritis is an immune-mediated inflammatory disease of the diarthroidal joints (movable joints: shoulder, knee, etc.), which occurs in multiple joints, and in which the cartilage of the joint (articular cartilage) is not eroded away. A type III hypersensitivity reaction, which causes antibodies to be bound to an antigen, in this case joint tissue, causes this condition.
These antibody-antigen complexes are called immune complexes, and they are deposited within the synovial membrane (where the fluid that lubricates the joints is held). There, the immune complexes trigger an abnormal immune response to the joint cartilage. What this means is that, in effect, the body is fighting against itself. This leads to an inflammatory response, and complement protein activation by the tissue surrounding the cartilage, in response to the immunity displaying cells, leading to the clinical signs of arthritis.
You will need to give your veterinarian a thorough history of your dog's health leading up to the onset of symptoms. Your veterinarian will perform a thorough physical exam on your dog, taking note of signs of pain, decreased range of motion, and any lameness. A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, a urinalysis, and an electrolyte panel. In dogs suspected to have lupus erythematosus, a lupus erythematosus preparation or an antinuclear antibody test can be performed. Joint fluid aspirate will be taken for lab analysis, and submitted for bacterial culture and sensitivity. A biopsy (tissue sample) of synovial tissue will also help to make a definitive diagnosis.
X-ray images can also be used as a diagnostic tool. If a nonerosive, immune-mediated polyarthritis condition is present, it will be visible on the radiograph image.
A product made of fluid, cell waste, and cells
A medical condition in which the smooth muscles become inflamed
A medical condition in which the ear becomes inflamed
A record of body structures using an x-ray
A medical condition in which the synovial membrane becomes inflamed
The hollow bodily organ that holds the embryo and fetus and provides nourishment; only found in female animals.
An in-depth examination of the properties of urine; used to determine the presence or absence of illness
A medical condition in which the meninges becomes inflamed
The displacement of the bone from its joint
The dislocation of a bone from the joint
a) inhaling b) getting out fluid or gas by the act of sucking.
A medical condition in which the joints become inflamed and causes a great deal of pain.
Any substance or item that the body of an animal would regard as strange or unwanted; a foreign disease or virus in the body (toxin, etc.)
The process of removing tissue to examine it, usually for medical reasons.
An inflammation of the lining of the heart
Any type of pain or tenderness or lack of soundness in the feet or legs of animals
A reaction to a certain pathogen that is out of the ordinary
A protein in the body that is designed to fight disease; antibodies are brought on by the presence of certain antigens in the system.
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