Hi stranger! Signing up for MypetMD is easy, free and puts the most relevant content at your fingertips.

Get Instant Access To

  • 24/7 alerts for pet-related recalls

  • Your own library of articles, blogs, and favorite pet names

  • Tools designed to keep your pets happy and healthy

or Connect with Facebook

By joining petMD, you agree to the Privacy Policy.

Prednisone Prednisolone

Drug Details

  • Drug Name: Prednisone Prednisolone
  • Common Name: Prednis-Tab®
  • Drug Type: Corticosteroid
  • Used For: Inflammation, Cancer, Addison’s disease, Nervous system disorders
  • Species: Dogs, Cats
  • Administered: Tablets, Oral liquid, Injectable
  • How Dispensed: Prescription only
  • FDA Approved: Yes

General Description


Prednisone and Prednisolone are steroids that reduce inflammation and suppress the immune system. They can be beneficial in treating many diseases and disorders, but should be given at low doses for short period of time to reduce any adverse effects. They may also be used to assist in treatment of Addison’s disease, cancers, shock, and nervous system disorders.

How It Works


Prednisolone is a corticosteroid known as a glucocorticoid. Corticosteroids are meant to resemble a naturally occurring hormone produced in the adrenal cortex, cortisol. Corticosteroids act on the immune system by blocking the production of substances that trigger inflammatory and immune responses.


In your pet’s liver, prednisone is converted to prednisolone. Pets with severe liver problems are not able to make this conversion, and many believe that these pets should only be given prednisolone.


Storage Information


Store in a tightly sealed container at room temperature.


Missed Dose?


It is important that you do not miss any doses of this drug and you should give it at about the same time every day at even intervals. If you do miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once.


WATCH: How to Give a Pet Pills


Side Effects and Drug Reactions


Prednisone/Prednisolone may result in these side effects:

  • Increased drinking and urination
  • Altered behavior
  • Inhibited growth in young pets
  • Diabetes after prolonged use
  • Cushing’s disease after prolonged use
  • Panting
  • Vomiting
  • Diarrhea
  • Ulceration of the digestive tract
  • Lethargy
  • Aggression
  • Delayed healing


Prednisone/Prednisolone may react with these drugs:

  • Rimadyl (or any other NSAID)
  • Antacids
  • Anticoagulants
  • Other steroids
  • Some antibiotics
  • Drugs that may cause ulcers in the digestive tract
  • Vaccines





Discover More Medications