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Skin Tumor (Histiocytoma) in Dogs


Histiocytoma in Dogs


A histiocytoma is a benign skin tumor that originates in the Langerhans cells, immune cells that function to provide protective immunity to the tissues that are in contact with the outer environment -- the nose, stomach, intestines and lungs, but mainly the skin's surface. These cells are also referred to as dendritic cells, and histiocytes.


Histiocytomas are common in dogs, with some breeds appearing to be more predisposed that others. These breeds include flat-coated retrievers, bull terriers, boxers, dachshunds, cocker spaniels, Great Danes, and Shetland sheepdogs. More than 50 percent of diagnosed patients are under two years of age. Otherwise, there is no gender difference.




  • Small, firm, dome or button-shaped masses on the skin surface
  • Rare autoimmune blistering (dermoepithelial) masses, which may be ulcerated
  • Fast growing, nonpainful, usually solitary
  • Common sites are the head, ear edges, and limbs
  • Occasionally multiple skin nodules or plaques








You will need to give a thorough history of your dog's health and onset of symptoms, after which your veterinarian will perform a thorough physical exam. A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, a urinalysis and an electrolyte panel. Most of these tests return as normal.


Other diagnostic tests include a cytologic examination (a microscopic examination of the cells) using a sample gathered by fine-needle aspirate. This may reveal pleomorphic round cells (cells taking one or more forms), with variable-sized and -shaped nuclei. It is common to find that the mitotic index (a measure of the proliferation, or fast production status of a cell population) is high. The tests may also show evidence of substantial lymphocyte (white blood cell in the vertebrate immune system), plasma cell, and neutrophil (the most abundant type of white blood cells) infiltration.




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