Anemia, Megaloblastic (Anemia, Nuclear Maturation Defects) in Dogs

In this disease, red blood cells fail to divide and become abnormally large. These cells are also deficient in necessary DNA material. These giant cells with underdeveloped nuclei are called megaloblasts, or “big cells.” Red blood cells are mainly affected, but white blood cells and platelets can also go through changes.

Giant schnauzers seem to have an inherited tendency to have this kind of anemia. In dogs, it is generally mild, and left treated. The seriousness of the anemia can range from mild to severe. This disease is genetic in Toy Poodles, but it does not require treatment.

The condition or disease described in this medical article can affect both dogs and cats. If you would like to learn more about how this disease affects cats, please visit this page in the PetMD health library.

Symptoms and Types

• Anorexia
• Diarrhea
• Pale skin color
• Weakness
• Sore mouth and tongue

Causes

• Deficiencies of Vitamin B-12 and folic acid
• Leukemia
• Bone marrow disorder
• Genetics
• Drugs such as chemotherapy

Diagnosis

Tests will be conducted to rule out the following:

• All mild to moderate non-regenerative anemias, including those of inflammatory disease, renal disease, and lead poisoning
• Complete blood counts will be taken and bone marrow aspiration analysis

Complete blood count, biochemistry, and urinalysis will examine the following:

• Is the anemia mild or moderate?
• Is the anemia caused by over-sized cells?
• Bone marrow biopsy usually reveals if there are an abnormal amount of cells