Myelodysplastic syndromes are a group of disorders affecting the dog's hematopoietic stem cells, which forms all the types of blood cells in the body (i.e., red blood cells, white blood cells, platelets). These disorders are characterized by the abnormal development and maturation of hematopoietic stem cells, and may be primary (congenital) or secondary (due to cancer, drugs exposure, and/or infections).
Myelodysplastic syndromes more common in cats than dogs.
You will need to give a thorough history of your dog’s health, including the onset and nature of the symptoms, to your veterinarian. He or she will then conduct a complete physical examination, as well as a biochemistry profile, urinalysis, and complete blood count (CBC). Blood testing is especially important in making the diagnosis, as it may reveal abnormal reduction in the number of blood cells (cytopenia). In some dogs, megaloblastic anemia is also seen.
Other abnormal findings may include large, bizarre platelets and immature granulocytes (type of white blood cells) with abnormal shape and sizes. Your veterinarian will also take bone marrow sample to evaluate the red blood cell and white blood cells production process and identify abnormalities.
The prediction of a disease’s outcome in advance
An in-depth examination of the properties of urine; used to determine the presence or absence of illness
A decrease in the number of neutrophilic leukocytes in an animal’s blood
The type of female hormone produced in the ovaries that contributes to sex drive and female characteristics
A condition in which growth and development are not up to normal standards
A condition of the blood in which normal red blood cell counts or hemoglobin are lacking.