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Drug Details

  • Drug Name: Ursodiol
  • Common Name: Actigall®, Urso®
  • Drug Type: Bile acid
  • Used For: Liver and Gall Bladder diseases, prevention and treatment of gallstones
  • Species: Dogs, Cats
  • Administered: Tablet
  • How Dispensed: Prescription only
  • FDA Approved: No

General Description


Ursodiol is a bile acid given to cats and dogs for the treatment and prevention of gallstones. It is also used in the treatment of chronic liver problems.


Ursodiol is not FDA approved for veterinary use, but it is common practice for veterinarians to prescribe this medication. Give this medication with food, as this will increase absorption.


How It Works


Ursodiol reduces the uptake of cholesterol, as well as the synthesis and production of cholesterol. This is thought to help dissolve gall stones, which is a pebble-like formation containing cholesterol.


Ursodiol also helps pets with chronic liver diseases by increasing the flow of bile acids, preventing the build-up of toxic bile acids.


Storage Information


Store Ursodiol in a tightly sealed container at room temperature.


Missed Dose?


Give the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.


Side Effects and Drug Reactions


Ursodiol may result in these side effects:

  • Allergic reaction (labored breathing, hives, etc)
  • Worsened liver disease (vomiting, diarrhea, jaundice)


Ursodiol may react with these drugs:

  • Tylenol (Acetaminophen)
  • Estrogens
  • Antacids containing aluminum
  • Vitamins and other supplements


Please consult your veterinarian before giving these or any other drug or herbal supplement to your pet while on Ursodiol.




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