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Drug Details

  • Drug Name: Fluoxetine
  • Common Name: Reconcile®, Prozac®
  • Drug Type: SSRI (selective serotonin re-uptake inhibitors)
  • Used For: Separation anxiety, aggression
  • Species: Dogs, Cats
  • Administered: Capsules, Tablets, Oral liquid
  • How Dispensed: Prescription only
  • FDA Approved: Yes, for dogs

General Description


Fluoxetine is used by veterinarians to reduce anxiety and aggression in dogs and cats. It is the equivalent to the human drug Prozac.


How It Works


Fluoxetine increases serotonin levels within the central nervous system by allowing it to accumulate and effect the part of the brain that is responsible for social interactions, general awareness, coping mechanism and adaptability. It may take up to 4 weeks to see results.


Storage Information


Store at room temperature. Do not remove desiccant canister from the bottle. Completely close bottle between uses.


Missed Dose?


If you miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.


Side Effects and Drug Reactions


Fluoxetine may result in these side effects:


  • Loss of appetite - most common, usually temporary
  • Lethargy
  • Vomiting
  • Tremor
  • Diarrhea


Fluoxetine may react with these drugs:


  • Acepromazine
  • Amitraz (including the flea/tick collars and dips)
  • Buspirone
  • Cyproheptadine
  • Diazepam
  • Alprazolam
  • Diuretics
  • Insulin
  • Isoniazid
  • MAO inhibitors (selegiline)
  • Pentazocine
  • Phenytoin
  • Propanolol
  • Metoprolol
  • Tramadol
  • Tricyclic antidepressants
  • Trazodone
  • Warfarin

An overdose of fluoxetine may result in seizure. Contact your veterinarian immediately if your dog begins to seize.


An allergic reaction may cause swelling, hives, scratching, vomiting, or seizing. Contact your veterinarian immediately if you suspect an allergic reaction.


The safety of using fluoxetine in pregnant animals has not been determined. Do not use in lactating animals, since the drug enters the breast milk.


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