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Drug Details

  • Drug Name: Cisapride
  • Common Name: Propulsid®
  • Drug Type: Gastrointestinal prokinetic
  • Used For: Megaesophagus, Acid reflux, Megacolon
  • Species: Dogs, Cats
  • Administered: Compounded medication
  • How Dispensed: Prescription only
  • FDA Approved: No

General Description


Cisapride is given to help with the quick passage of food through the digestive tract. It may be used to treat disorders such as megaesophagus, acid reflux disease, megacolon. It is also effective against chronic constipation and some causes of vomiting.


This drug was discontinued for use in humans due to severe side effects (including heart rhythm abnormalities) due to reactions to other drugs prescribed by different doctors. Due to the fact that pets typically go to one practice, complications in pets is fairly uncommon.


How It Works


The muscles in the stomach contract to pass food at a certain pace known as it’s motility. Motility can be inconsistent or abnormal due to a number of disorders. Reduced motility leads to a build-up of food in the stomach which causes bloating and nausea. Cisapride increases the release of acetylcholine, which in turn stimulates the smooth muscle in the digestive tract to contract more frequently.


Storage Information


Store in a tightly sealed container at room temperature.


Missed Dose?


Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.


Side Effects and Drug Reactions


  • Cisapride may result in these side effects:
  • Allergic reaction (seizures, hives, etc)
  • Diarrhea
  • Abdominal pain


Cisapride may react with these drugs:


  • Cimetidine
  • Itraconazole
  • Ketoconazole
  • Ranitidine
  • Anticholinergic
  • Anticoagulant
  • Diazepam




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