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Severe combined immunodeficiency (SCID) is an autosomal (not linked to the chromosomes for sex) recessive genetic disease affecting Arabian foals. These foals cannot produce B and T lymphocytes, which are special types of white blood cells that are vital for a healthy immune system. Without B and T lymphocytes, the immune system cannot fight antigens properly.
SCID-affected foals seem normal at birth, but after the first few months of life, they begin to suffer from a variety of infections. This time period coincides with the loss of the protective maternal antibodies they ingested from their mother’s milk at birth.
One of the most common causes of infection in SCID foals is adenovirus, which causes a severe bronchopneumonia. Other types of infections can involve bacteria, fungal, and protozoal infections. Testing for the SCID gene is now commercially available.
Symptoms will vary according to the type of infection the foal succumbs to, including:
This genetic defect results in a deletion of a gene that prevents production of an enzyme necessary for the maturation of B and T lymphocytes (a type of white blood cell), which are needed to fight off infections.
In the past, testing was done by observing for clinical signs and checking complete blood count results for a consistent dearth of lymphocytes. To support a diagnosis, a lab-run radial immunodiffusion test was performed. If it showed no serum IgM (a type of antibody) in presuckling blood, then the foal was diagnosed with SCID.
Currently, a genetic test for SCID is available. This commercial test requires a sample of whole blood or cheek swabs and is dependent on polymerase chain reaction (PCR) techniques to amplify the foal’s DNA present in the sample. This test can also reveal carriers of the gene so as to allow horse owners to prevent two carriers from breeding, which increase the chances of producing an SCID foal.
The term for a female horse over the age of four that has not been sterilized
A horse that is four years of age or older; a stallion is intact
A substance that causes chemical change to another
A condition of the lungs and bronchi in which they become inflamed and congested.
Any substance or item that the body of an animal would regard as strange or unwanted; a foreign disease or virus in the body (toxin, etc.)
A protein in the body that is designed to fight disease; antibodies are brought on by the presence of certain antigens in the system.
Having a hard time breathing; breathing takes great pains