Hi stranger! Signing up for MypetMD is easy, free and puts the most relevant content at your fingertips.

Get Instant Access To

  • 24/7 alerts for pet-related recalls

  • Your own library of articles, blogs, and favorite pet names

  • Tools designed to keep your pets happy and healthy

or Connect with Facebook

By joining petMD, you agree to the Privacy Policy.

PetMD Seal

Phosphofructokinase Deficiency in Dogs



Phosphofructokinase is the most important rate-controlling enzyme required for glycolysis, the metabolic pathway that coverts glucose into pyruvate, thereby releasing energy to be used for a variety of functions such as maintaining the shape of red blood cells. Phosphofructokinase deficiency also greatly inhibits the energy skeletal muscles require for exercising.


This metabolic disorder has a genetic basis, mainly affecting English Springer spaniels, American cocker spaniels, and mixed-breed dogs.


Symptoms and Types


Symptoms associated with this disorder will depend on the severity of the phosphofructokinase deficiency. Some of the more common ones include:


  • Fever
  • Depression
  • Lethargy or general weakness
  • Blood in urine (hematuria)
  • Pale mucous membranes
  • Muscle wasting and cramping
  • Exercise intolerance




A deficiency in the phosphofructokinase enzyme.




You will need to give a thorough history of your dog’s health to your veterinarian, including the onset and nature of the symptoms. He or she will then perform a complete physical examination as well as a complete blood test, biochemical profile, and urinalysis.


Blood testing will typically reveal anemia and other red blood cell abnormalities. A biochemistry profile, meanwhile, will usually show abnormally high levels of potassium, calcium, magnesium, urea, and total protein. Bilirubin levels will particularly be high (which can also be confirmed with the urinalysis) due to the increased destruction of red blood cells and subsequent release of bilirubin. Your veterinarian may also suggest DNA testing, such as a poly chain reaction test (PCR), to identify carrier dogs, or run further testing to measure the levels of phosphofructokinase enzyme.




Related Articles

Diabetes with Coma in Dogs

In the case of diabetes mellitus, the pancreas is not capable of making enough insulin. When this happens, the blood sugar level remains too...

Diabetes in Dogs

Diabetes mellitus is a diseased state by which the body suffers from either an absolute shortage of insulin, or from an incorrect response from...

Thyroid Gland Disorder in Dogs

Myxedema coma is a rare condition in dogs characterized by an under-functioning thyroid gland (hypothyroidism). Affected dogs become cold, extremely...

Overproduction of Estrogen in Dogs

Overproduction of estrogen can result in what is known as estrogen toxicity (hyperestrogenism). This can happen without any outside interference...