Skin Diseases from Allergies in Dogs

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Eosinophilic Granuloma Complex in Dogs

In dogs, the eosinophilic granuloma complex is a sometimes confusing term for three distinct syndromes that cause inflammation and irritation of the skin:

  • Eosinophilic plaque - circumscribed, raised, round to oval lesions that frequently are ulcerated. They are usually located on the abdomen or thighs. These lesions contain a type of white blood cell called an eosinophil.
  • Eosinophilic granuloma - a mass or nodular lesion containing eosinophils usually found on the back of the thighs, on the face, or in the mouth.
  • Indolent ulcer – circumscribed, ulcerated lesions most frequently found on the upper lip. 

Eosinophilic refers to eosinophils, a type of white-blood cell usually involved in allergic responses. Granuloma is a large inflammatory nodule or solid mass. And a complex is a group of signs or diseases that have an identifiable characteristic that makes them similar in some fashion.

Note that in dogs, eosinophilic granulomas are rare and are not part of the eosinophilic granuloma complex. eosinophilic granulomas do occur in dogs and other species, they are not considered part of the eosinophilic granuloma complex. granuloma complex is restricted to cats. However, dogs can be afflicted with eosinophilic granulomas, and that will be covered here.

Eosinophilic plaque is circumscribed, raised, round-to-oval lesions that frequently are ulcerated and usually appear on the abdomen or thighs. The lesions contain a type of white blood cell called an eosinophil and usually appear between the ages of two and six years. Genetically initiated eosinophilic granuloma will be seen in dogs that are younger than two years of age.

Allergic disorders usually develop after a dog has reached the age of two, with allergy related eosinophilic granuloma becoming apparent before the dog has reached three years of age.

The genetics are unknown, although several reports indicate that in at least some individuals, genetic susceptibility (perhaps resulting in an inheritable dysfunction of eosinophils) is a significant component of the disease. With eosinophilic granuloma in dogs, Siberian huskies account for 76 percent of the cases, and mmake up 72 percent of the cases of eosinophilic granuloma in affected dogs.

Symptoms and Types

Lesions of more than one syndrome may occur simultaneously. In dogs, you may notice one or more ulcerated masses that are thick with a flat top, and that appear dark or orange in color.

Eosinophilic plaques:

  • Circumscribed, raised, round to oval lesions frequently ulcerated
  • Moist or glistening plaques (may have enlarged lymph nodes)
  • Abdomen
  • Near the chest
  • Inner thigh area
  • Near the anus
  • Under front legs
  • Hair loss
  • Red skin
  • Erosions

Eosinophilic granulomas:

  • Linear orientation
  • Back of the thigh
  • Multiple lesions coming together
  • Coarse, cobblestone pattern
  • White or yellow
  • Lip or chin swelling (edema)
  • Footpad swelling
  • Pain
  • Lameness

Indolent ulcer:

  • Ulcers of the mouth
  • Found on upper lip
  • Within the oral cavity, ulcers on gums
  • Slightly raised margins
  • Non-bleeding
  • Usually painless
  • May transform into a more malignant cancerous form (carcinoma)


  • Non-specific allergies
  • Allergic hypersensitivity reaction
  • Food allergy
  • Fleas
  • Insects
  • Genetic predisposition


Your veterinarian will perform a complete physical exam on your dog. You will need to give a thorough history of your dog's health, onset of symptoms, and possible incidents that might have preceded this condition, such as an allergic reaction or flea infestation. Any information you have about your dog's genetic background may also be helpful in diagnosing this disorder. Your veterinarian will order a blood chemical profile, a complete blood count, an electrolyte panel and a urinalysis as part of the diagnostic process.

The physical exam should include a dermatologic exam, during which skin biopsies for a histopathology study will be taken. Skin scrapings will also be examined microscopically and cultured for the presence of bacteria, mycobacteria and fungi. Impression smears of the lesions should also be taken.

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