Infertility in Female Dogs

PetMD Editorial
By PetMD Editorial on Apr. 27, 2010
Infertility in Female Dogs

Inability to Reproduce in Female Dogs

Some of the common symptoms that appear in bitches which are unable to reproduce are abnormal cycling, failure to conceive, failure to copulate/mate, and pregnancy loss. Normal fertility in a dog, and the ability to reproduce puppies, requires a normal estrous cycle, with a healthy reproductive tract, normal ova (eggs), normal and stable levels of reproductive hormones, fertilization by normal spermatozoa, implantation of an embryo in the lining of the uterus (endometrium), normal placenta placement, and stable levels of progesterone concentration. These conditions must be maintained for the entirety of the two month gestational period, or the process of reproduction will be altered, with resultant infertility.


  • Failure to copulate (i.e., an inability to successfully mate with a male dog)
  • Normal copulation without subsequent pregnancy
  • Too frequent cycling
  • Failure to cycle


Infertility can affect dogs of all ages, but tends to be more common among older dogs. An underlying cystic endometrial hyperplasia -- uterine cysts -- is more common among dogs past the age of six. Dogs that have had previous uterine infections can also have subsequent difficulties with implantation. However, one of the most causes of seeming infertility is insemination during the improper time in the estrous cycle.


Dog breeds that are predisposed to thyroids insufficiency have a higher prevalence of fertility problems. Breeds that are at particular risk of hypothyroidism are boxers, Doberman pinschers, dachshunds, golden retrievers, great Danes, Irish setters, miniature schnauzers, and poodles.

Other conditions that may play a role in the dog's ability to reproduce include:

  • Male infertility factors
  • Sub-clinical uterine infections
  • Brucella canis
  • Canine herpesvirus
  • Toxoplasmosis infection
  • Hypercortisolism
  • Thyroid insufficiency
  • Abnormal ovarian functions
  • Chromosomal abnormality
  • Systemic viral or protozoal infection
  • Lack of sufficient copulatory stimulus in order to induce ovulation


Your veterinarian will perform a thorough physical exam on your dog, taking into account the background history of symptoms and possible incidents that might have led to this condition. There are several diagnostic tests that can be conducted in order to find out if the symptoms are related to the infertility disorder.

Some of the basis for the diagnosis will be related to whether your dog has conceived or given birth in the past. If she has reproduced successfully before, your veterinarian will consider whether the male mate that has been chosen for breeding is of proven fertility, or whether the timing for the breeding was scheduled in accordance with your dog's ovulation cycle.  

Your dog's hormone levels will be analyzed, to be sure that she has the required levels for conception and a following pregnancy. Progesterone concentration must remain steady throughout the pregnancy for it to be successful.

A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, and a urinalysis. These tests will show evidence of infections, either bacterial, viral, or parasitic. Viral infections that will be tested for include toxoplasmosis, protozoal parasite infection, canine herpesvirus, hypercorticolism, hypothyroidism, and Brucella canis. In addition, your doctor will be checking your dog's body thoroughly for any other chronic disease conditions.

Imaging techniques may be used to look for any abnormalities in the uterus, such as masses (indicating tumors), and anatomic abnormalities that would interfere with conception. In a healthy dog, the ovaries and uterus will not be visible on X-ray imaging. If your veterinarian is able to view the ovaries or uterus, this would suggest that there may be an underlying condition of ovarian cysts, ovarian cancer, or uterine cysts. If it appears, on examination, that your dog has cysts or other masses of tissue in the uterus or reproductive tract, your veterinarian will need to take a sample of tissue from the uterus for biopsy.



Improper breeding is most often at the root of the perceived infertility. To prevent this, the male dog may be bred to another bitch to test his ability to impregnate. Another alternative may be the use of gonadotropin, a hormone which induces ovulation in animals unable to do so normally.

If improper breeding does not seem at fault, your veterinarian will begin treatment for other underlying causes for infertility. For example, antibiotics are given if a uterine infection is suspected. Some of the surgical considerations include surgical repair of the obstructed reproductive tract, surgical correction of abnormalities in the vagina, removal of a cancerous ovary, and either draining or surgically removing the ovarian cysts. If your dog is found to have an underlying condition of hypothyroidism, your veterinarian will treat the condition, and will probably advise you not to breed your bitch, as this disease is often genetically inherited and passed on to further generations.

Living and Management

Your veterinarian will schedule a follow-up exam to test your dog's progesterone hormone levels, and to perform an ultrasonography exam to confirm a healthy pregnancy and placental position. If L-Thyroxine is prescribed, he or she will examine the dog after one month in order to ensure proper absorption.

Help us make PetMD better

Was this article helpful?

Get Instant Vet Help Via Chat or Video. Connect with a Vet. Chewy Health