Anemia, Nonregenerative in Dogs

PetMD Editorial
By PetMD Editorial on Aug. 12, 2008
Anemia, Nonregenerative in Dogs

Non-regenerative Anemia in Dogs

A decrease in red blood cells is called anemia. Typically, bone marrow will respond to this decrease by increasing red blood cell production. However, in non-regenerative anemia, the bone marrow response is inadequate when compared to the increased need. For this reason, dogs who suffer from anemia caused by lead poisoning are put in a very dangerous situation. Also, dogs that become anemic over a period of time will fare better than those who have a sudden onset of anemia. When the anemia progresses slowly, the body has time to adjust to the decreased red blood cell count. Dogs that become anemic quickly may die because of the sudden loss in red blood cells and oxygen.

There are three kinds of anemia: blood loss anemia caused by blood leaking out of the vascular system, as in the case of a wound; hemolytic anemia results from the destruction of red blood cells circulating within the blood stream; and non-regenerative anemia, which is caused by a decrease in red cell production.

The condition or disease described in this medical article can affect both dogs and cats. If you would like to learn more about how this disease affects cats, please visit this page in the PetMD health library.

Symptoms and Types

  • Pale gums or mucous membrane
  • Eyes and ears may be pale as well
  • Weakness
  • Depression
  • Sleeping more than normal
  • Stop grooming themselves
  • Decreased appetite
  • Increased breathing and heart rate



  • Bone marrow disease
  • Infections (tick disease)
  • Abscesses
  • Cancer
  • Kidney failure
  • Drugs
  • Toxic chemicals
  • Radiation
  • Lead poisoning
  • Inherited disorders (giant Schnauzers, Border collies, and Beagles are most at risk)



Anemia is generally a symptom of another disease. Therefore, diagnosis is based on your dog's history and clinical symptoms, physical examination, complete blood counts, urinalysis, iron testing, and bone marrow testing.



Once the cause of the non-regenerative anemia is determined, it can usually be resolved by treating the underlying disease. If the case is severe (and if the blood is also deficient in white blood cells and the blood platelets in the circulating blood), the prognosis will be guarded and will require long-term treatment. A complete resolution of this type of anemia does not usually occur.

If the non-regenerative anemia has developed slowly, it may not require treatment. However, the animal may need to have its exercise restricted to a minimum, and occasional transfusions may be required. If blood loss and/or shock have led to severe reduction in blood volume and in the supply of blood to tissues, a medicating solution called Ringer’s may be injected.

Living and Management

Because of the severity of the condition, you should be prepared for a long period of recovery. You will need to take your pet to the veterinarian frequently; as often as every one or two days in the preliminary stages, both to see the dog's progress and possibly for treatment. Eventually the time between visits will decrease to every one or two weeks, depending on the rate of recovery.

Follow your veterinarian's recommendations for treatment and medications. Most importantly, do not attempt any treatment that has not recommended or approved by your doctor.

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