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Overproduction of White Blood Cells in the Bone Marrow in Dogs



Long-term maintenance therapy will be employed to control or reduce the eosinophilia and organ damage. High serum immunoglobulin concentrations (the fraction of the blood serum that contains antibodies) can signify a good response to treatment with prednisone, a corticosteroid given to reduce inflammation, and therefore a better prognosis. Prednisone can be effective at suppressing eosinophil production. In some cases, chemotherapy may be appropriate for inhibiting DNA synthesis, in effect, reducing the reproduction of cells. Massive tissue infiltration can impede treatment and usually leads to a poor prognosis.


Living and Management


Your veterinarian will schedule follow-up examinations for your dog to monitor eosinophil count (not always indicative of tissue infiltrates) and myelosuppression (by which bone marrow activity is decreased) if chemotherapeutic drugs are being used. Clinical signs will also be monitored along with any physical abnormalities (e.g. loss of appetite, lethargy, vomiting, and diarrhea).



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