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The best defense is sometimes a good offense—and that’s especially true when it comes to protecting your cat from flea and tick infestations. A good flea and tick program will help protect your cat from these parasites, reducing their risk of experiencing allergic reactions or contracting a tick- or flea-borne illness.

Fleas and ticks are ectoparasites, meaning they live outside your animal (as opposed to other parasites, like intestinal worms, which live internally). They are blood feeders, so they rely on sucking blood from their host animal to stay alive. Fleas are linked to multiple health issues in cats, including allergic reactions, dermatitis, anemia, infections, and tapeworms. Tick bites can also transmit potentially serious infections to cats like hemobartonellosis, cytauxzoonosis, tularemia, and more.

There are a wide range of parasite preventatives on the market. When it comes to choosing the best one, your vet can help recommend a product that is right for your cat based on their age, lifestyle, where you live, and what pests pose a threat. Combination products can address both fleas and ticks, as well as a host of other parasites.

Flea & Tick Combination Treatment for Cats

A few common flea and tick combination products are listed below.

Advantage® Multi contains the active ingredients imidacloprid and moxidectin and begins killing fleas within hours of administration. Advantage® Multi also treats hookworms, roundworms, and ear mites and prevents heartworm disease. According to the product label, this product should only be used in cats and kittens over 9 weeks of age and weighing at least 2 lbs. Advantage® Multi is a topical product that is applied monthly according to the label instructions.

Bravecto® contains the active ingredient fluralaner, which is in the isoxazoline class of products.  Isoxazoline producsts should be used with caution and only under a vet’s supervision in cats with a history of seizures and other neurologic disorders. Bravecto® is effective in the treatment of fleas and black-legged ticks for 12 weeks, and American dog ticks for 8 weeks. Clinical studies show it is safe for use in cats and kittens older than 6 months of age and weighing at least 2.6 pounds. It is offered in formulations for cats weighing between 2.6-6.2 lbs., 6.2-13.8 lbs., and more than 13.8 lbs. Bravecto® is applied topically every 8 to 12 weeks according to the label directions.

Bravecto® Plus contains the active ingredients fluralaner and moxidectin. Like Bravecto®, this product is in the isoxazoline class, so it should be used with caution and only with veterinary supervision in cats with a history of seizures or other neurologic disorders. Together, the ingredients in Bravecto® Plus have been shown to treat and prevent flea, tick, and ear mite infestations, as well as controlling roundworms and hookworms and preventing heartworm disease. Bravecto® Plus is a topical medication that is applied every 2 to 3 months, according to the label directions. It is safe for use in cats who are 9 weeks of age and older and 2.6 pounds and heavier.

Credelio® contains the active ingredient lotilaner, also part of the isozazoline class of products. This medication has been shown to start killing fleas within hours of administration. According to the manufacturer, it is effective against fleas in cats and kittens over 8 weeks of age and weighing at least 2 lbs. It has also been shown in clinical trials to kill deer ticks in cats and kittens over six months of age. Credelio® is administered monthly as a chewable tablet. Credelio® is in the isoxazoline class of medications, so should be used with caution and only under vet supervision in cats with a history of seizures or other neurologic disorders.

Frontline® Gold contains the active ingredients fipronil, (s)-methoprene, and pyriproxyfen. This combination of ingredients has been shown to control multiple life stages of fleas, as well as ticks, mosquitoes, and chewing lice. Frontline® is applied monthly as a topical solution, according to the label instructions. It has been shown to be safe for use in cats and kittens 8 weeks of age and older and weighing more than 1.5 lbs.

Frontline® Plus contains the active ingredients fipronil and (s)-methoprene. This combination of ingredients has been shown to kill multiple life stages of fleas, as well as ticks, and chewing lice. According to the product label, it is safe for use in cats and kittens over 8 weeks of age and weighing more than 1.5 pounds. Frontline® Plus is applied monthly as a topical solution according to the product instructions.

Revolution® Plus contains the active ingredients selamectin and sarolaner. This combination of ingredients kills multiple life stages of fleas as well as ticks, ear mites, roundworms, and hookworms. It also prevents heartworm disease. According to the product label, Revolution® Plus is safe for use in cats and kittens who are at least 8 weeks of age and weigh 2.8 lbs. or more. It is applied every month as a topical solution according to the label instructions.

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