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No specific treatment for the viral infection itself is available, but fluid therapy, nutritional support, and antibiotics for secondary bacterial infections can help many animals recover.
The adenovirus is highly contagious, so any reptile that is suspected to have the infection must be completely isolated from other reptiles for 90 days to prevent the spread of the disease. New additions to a reptile collection should also be quarantined to reduce the chances of introducing adenovirus into the group.